1965年至2023年发现的生物活性安古环素/安古环酮类化合物

Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023.

作者信息

Liu Hai-Shan, Chen Hui-Ru, Huang Shan-Shan, Li Zi-Hao, Wang Chun-Ying, Zhang Hua

机构信息

School of Biological Science and Technology, University of Jinan, 336 West Road of Nan Xinzhuang, Jinan 250022, China.

出版信息

Mar Drugs. 2025 Jan 5;23(1):25. doi: 10.3390/md23010025.

DOI:10.3390/md23010025

PMID:39852527

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11766693/

Abstract

Angucyclines/angucyclinones, a class of polyketides with diverse chemical structures, display various bioactivities including antibacterial or antifungal, anticancer, anti-neuroinflammatory, and anti-α-glucosidase activities. Marine and terrestrial microorganisms have made significant contributions to the discovery of bioactive angucyclines/angucyclinones. This review covers 283 bioactive angucyclines/angucyclinones discovered from 1965 to 2023, and the emphasis is on the biological origins, chemical structures, and biological activities of these interesting natural products.

摘要

安古环素/安古环酮是一类具有多样化学结构的聚酮化合物，具有多种生物活性，包括抗菌或抗真菌、抗癌、抗神经炎症和抗α-葡萄糖苷酶活性。海洋和陆地微生物对生物活性安古环素/安古环酮的发现做出了重大贡献。本综述涵盖了1965年至2023年发现的283种生物活性安古环素/安古环酮，重点关注这些有趣天然产物的生物来源、化学结构和生物活性。