Raskin R E, Krehbiel J D
Department of Pathology, Michigan State University, East Lansing.
Vet Pathol. 1988 Jan;25(1):83-8. doi: 10.1177/030098588802500112.
Bone marrow core biopsies from 63 dogs with malignant lymphoproliferative disorders and leukemic involvement were evaluated. Multicentric lymphoma (44), multiple myeloma (8), chronic lymphocytic leukemia (9), and acute lymphoblastic leukemia (2) were found. Four distinct bone marrow histologic patterns were identified: focal (6), mixed (20), interstitial (28), and packed (9). Of those with focal or mixed patterns, 77% (20/26) had paratrabecular distribution. Stromal changes were infrequent, with 6% (4/63) having necrosis, 3% (2/63) fibrosis, and 6% (4/63) osteolysis. For each condition, the interstitial and mixed patterns were the most common presentations, while focal and packed patterns occurred less frequently. Morphologically, cells of metastatic lesions of lymphoma resembled those of primary sites. Colonization of bone marrow by various cytologic types of lymphoma was independent of the histologic patterns.
对63只患有恶性淋巴增生性疾病和白血病累及的犬进行了骨髓芯活检评估。发现有多中心淋巴瘤（44只）、多发性骨髓瘤（8只）、慢性淋巴细胞白血病（9只）和急性淋巴细胞白血病（2只）。确定了四种不同的骨髓组织学模式：局灶性（6只）、混合性（20只）、间质型（28只）和密集型（9只）。在局灶性或混合性模式的病例中，77%（20/26）具有小梁旁分布。基质变化不常见，6%（4/63）有坏死，3%（2/63）有纤维化，6%（4/63）有骨质溶解。对于每种情况，间质型和混合性模式是最常见的表现，而局灶性和密集型模式出现较少。形态学上，淋巴瘤转移灶的细胞与原发部位的细胞相似。各种细胞学类型的淋巴瘤在骨髓中的定植与组织学模式无关。
