Raskin R E, Krehbiel J D
Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing 48824.
J Am Vet Med Assoc. 1989 May 15;194(10):1427-9.
Multicentric lymphoma was diagnosed in 53 dogs. A study was performed to evaluate the prevalence of leukemic involvement in blood samples, bone marrow aspirates, and bone marrow core biopsy specimens at the time of initial diagnosis. Data indicated that 57% (30/53) of the dogs were leukemic when all materials were considered relative to the presence of cellular atypia or immaturity and abnormal tissue distribution. In the 30 leukemic dogs, detection was made in the specimens with the following frequency: 15 in blood (50%), 18 in bone marrow aspirates (60%), and 29 in bone marrow core biopsy specimens (97%). Five cases (17%) were only detected by core biopsy examination, even when dogs with bone marrow lymphocytosis of greater than 15% of nucleated cells were considered leukemic. Nondiffuse histologic colonization patterns accounted for the lack of correlation between the type of bone marrow specimens. Clinical staging for treatment response and prognosis was best determined by evaluation of concurrently obtained blood samples, bone marrow aspirates, and bone marrow core biopsy specimens.
53只犬被诊断为多中心淋巴瘤。开展了一项研究，以评估初诊时血液样本、骨髓穿刺物及骨髓芯针活检标本中白血病累及情况的患病率。数据表明，当所有材料均考虑细胞异型性或不成熟以及异常组织分布的存在时，57%（30/53）的犬患有白血病。在30只患白血病的犬中，各标本的检测频率如下：血液中15只（50%），骨髓穿刺物中18只（60%），骨髓芯针活检标本中29只（97%）。即使将有核细胞中骨髓淋巴细胞增多大于15%的犬视为患白血病，仍有5例（17%）仅通过芯针活检检查才被检测到。非弥漫性组织学定植模式导致骨髓标本类型之间缺乏相关性。治疗反应和预后的临床分期最好通过同时获取的血液样本、骨髓穿刺物及骨髓芯针活检标本进行评估来确定。
