J Am Vet Med Assoc. 2021 Jul 15;259(2):184-189. doi: 10.2460/javma.259.2.184.
A 16-year old castrated male domestic shorthair cat was evaluated at a veterinary teaching hospital because of polyuria, polydipsia, and weight loss of 2 months' duration.
Hematologic and biochemical examination results were within respective reference ranges except for moderately high pancreas-specific lipase concentration. Ultrasonographic and cytologic evaluation revealed a hepatic mass with findings consistent with mild cholestasis and inflammation and a pancreatic mass that was initially identified as a neuroendocrine tumor.
The cat underwent additional CT assessment and stereotactic body radiation therapy (SBRT; 3 fractions of 8 Gy, administered every other day) for treatment of the pancreatic tumor. Follow-up ultrasonographic and CT examinations indicated a partial response to SBRT, with a maximum CT-measured size reduction from 3.6 × 4.8 × 4.0 cm at the time of treatment planning to 2.0 × 2.0 × 1.9 cm 8 months later. Increased pancreatic tumor size and signs of carcinomatosis were detected 15 months after SBRT treatment; the initial cytologic diagnosis was changed to exocrine pancreatic carcinoma on reevaluation of the slides by another veterinary pathologist. Carboplatin treatment was elected, and signs of carcinomatosis resolved. The cat was euthanized without further testing because of weakness 589 days after SBRT was started.
To the authors' knowledge, this is the first report of SBRT for suspected exocrine pancreatic carcinoma in a cat. Further investigation is needed to determine optimal fractionation schedules for SBRT of pancreatic tumors and utility of SBRT of exocrine pancreatic carcinoma in cats.
一只 16 岁已去势的雄性家短毛猫因多尿、多饮和体重减轻 2 个月而在兽医教学医院接受评估。
除胰腺特异性脂肪酶浓度中度升高外，血液学和生化检查结果均在各自的参考范围内。超声和细胞学评估显示肝脏有肿块，伴有轻度胆汁淤积和炎症的表现，胰腺有肿块，最初被认为是神经内分泌肿瘤。
这只猫接受了额外的 CT 评估和立体定向体部放射治疗（SBRT；3 次 8 Gy，每隔一天进行 1 次）以治疗胰腺肿瘤。后续的超声和 CT 检查表明 SBRT 有部分反应，最大 CT 测量的大小从治疗计划时的 3.6×4.8×4.0 cm 减少到 8 个月后的 2.0×2.0×1.9 cm。SBRT 治疗 15 个月后发现胰腺肿瘤增大并出现癌转移迹象；重新评估另一兽医病理学家的幻灯片后，最初的细胞学诊断更改为外分泌胰腺腺癌。选择卡铂治疗，癌转移迹象得到缓解。SBRT 开始后 589 天，由于虚弱，这只猫被安乐死，没有进行进一步的检查。
据作者所知，这是首例报道 SBRT 治疗猫疑似外分泌胰腺腺癌。需要进一步研究以确定 SBRT 治疗胰腺肿瘤的最佳分割方案以及 SBRT 治疗猫外分泌胰腺腺癌的效用。
