原发性抗磷脂综合征中的骨坏死与既往使用糖皮质激素及血小板减少有关。
Osteonecrosis in Primary Antiphospholipid Syndrome is Associated with Previous Glucocorticoid Use and Thrombocytopenia.
作者信息
Freire de Carvalho Jozélio, Correia de Araujo Roberto Paulo, Skare Thelma Larocca
机构信息
Institute for Health Sciences, Federal University of Bahia, Rua das Violetas, 42, ap. 502, Pituba, Salvador, BA, Brazil.
Unit of Rheumatology, Hospital Evangélico Mackenzie, Curitiba, PR, Brazil.
出版信息
Rheumatol Ther. 2021 Sep;8(3):1255-1261. doi: 10.1007/s40744-021-00333-9. Epub 2021 Jul 6.
INTRODUCTION
The aim of this study was to investigate the frequency of avascular necrosis (AVN) and its associations with clinical and laboratory parameters in patients with primary antiphospholipid antibody syndrome (pAPS).
METHODS
This was a cross-sectional study of 66 patients with pAPS who fulfilled the Sidney criteria for APS. Epidemiological and clinical data, and data on antiphospholipid antibodies were collected. Diagnosis of AVN was based on studies of magnetic resonance (MRI) images of affected bones.
RESULTS
AVN was found in three of the 66 (4.5%) enrolled patients. Comparison of patients with pAPS with and without AVN showed that demographic data, comorbidities, and antiphospholipid antibodies profile were similar in both groups. Compared to patients without AVN, those with AVN had thrombocytopenia more frequently (66.7 vs. 7.9%) and used more glucocorticoids (100 vs. 35%).
CONCLUSION
AVN is rare in patients with pAPS and may be associated with thrombocytopenia and previous glucocorticoid use.
引言
本研究旨在调查原发性抗磷脂抗体综合征（pAPS）患者中无血管性坏死（AVN）的发生率及其与临床和实验室参数的关联。
方法
这是一项对66例符合APS悉尼标准的pAPS患者进行的横断面研究。收集了流行病学和临床数据以及抗磷脂抗体数据。AVN的诊断基于对受累骨骼的磁共振成像（MRI）研究。
结果
在66例纳入研究的患者中，有3例（4.5%）发现患有AVN。对有和没有AVN的pAPS患者进行比较，结果显示两组的人口统计学数据、合并症和抗磷脂抗体谱相似。与没有AVN的患者相比，患有AVN的患者血小板减少症更为常见（66.7%对7.9%），且使用糖皮质激素的比例更高（100%对35%）。
结论
AVN在pAPS患者中较为罕见，可能与血小板减少症和既往使用糖皮质激素有关。
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