Potashnik G, Homburg R, Eshkol A, Insler V, Lunenfeld B
Fertil Steril. 1978 Feb;29(2):148-52. doi: 10.1016/s0015-0282(16)43091-8.
Synthetic gonadotropin-releasing hormone (GnRH) in the form of nasal drops was self-administered by five amenorrheic patients in an attempt to assess its therapeutic value in anovulatory infertility. After follicular maturation had been induced with human menopausal gonadotropins (HMG), a total daily dose of 7.5 mg of GnRH in the form of nasal drops was self-administered at 2-hour intervals for 6 hours on 3 consecutive days. In four patients, plasma luteinizing hormone (LH) levels were significantly elevated over a period of at least 8 hours. In three of these patients, in addition, there was a definite upward shift in the basal body temperature (BBT) curve, and uterine bleeding occurred 6 to 9 days after the first dose of GnRH. In the fourth patient, ovulation was induced as indicated by a biphasic BBT curve, a plasma progesterone level of 13 ng/ml, and a luteal phase of 15 days. In the remaining patient, there was a borderline LH response and no clinical response. It is concluded that GnRH, in the form of nasal drops, is effective in eliciting and maintaining elevated plasma LH levels in patients in whom follicular maturation has been induced with HMG. By obtaining ovulatory LH levels, such a regimen can lead to ovulation. In addition, intranasal self-administration of GnRH is convenient and may provide an alternative route of administration for long-term therapy with this hormone.
五名闭经患者自行使用滴鼻剂形式的合成促性腺激素释放激素（GnRH），以评估其在无排卵性不孕症中的治疗价值。在用人类绝经期促性腺激素（HMG）诱导卵泡成熟后，连续3天每天以2小时间隔自行使用总量为7.5mg的滴鼻剂形式的GnRH，持续6小时。在四名患者中，血浆促黄体生成素（LH）水平在至少8小时内显著升高。此外，在其中三名患者中，基础体温（BBT）曲线有明显上升，且在首次使用GnRH后6至9天出现子宫出血。在第四名患者中，双相BBT曲线、血浆孕酮水平为13ng/ml以及黄体期为15天表明诱导了排卵。在其余患者中，LH反应处于临界状态且无临床反应。结论是，滴鼻剂形式的GnRH可有效促使并维持用HMG诱导卵泡成熟患者的血浆LH水平升高。通过达到排卵时的LH水平，这样的方案可导致排卵。此外，GnRH经鼻自我给药方便，可为该激素的长期治疗提供另一种给药途径。
