基于蒽光二聚体衍生的手性单膦配体实现的钯催化非对称分子间C-N偶联反应
Palladium-Catalyzed Desymmetric Intermolecular C-N Coupling Enabled by a Chiral Monophosphine Ligand Derived from Anthracene Photodimer.
作者信息
Wang Xin, Liu Wei-Gang, Liu Lan-Tao, Yang Xiao-Di, Niu Shu, Tung Chen-Ho, Wu Li-Zhu, Cong Huan
机构信息
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, School of Future Technology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100190, China.
College of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu, Henan 476000, China.
出版信息
Org Lett. 2021 Jul 16;23(14):5485-5490. doi: 10.1021/acs.orglett.1c01839. Epub 2021 Jul 6.
The development of chiral ligands with privileged scaffolds plays an important role in transition-metal-catalyzed asymmetric reactions. Herein we present anthracene-photodimer-derived chiral monophosphine ligand , which features dual chirality and a rigid scaffold. This ligand exhibits remarkable efficiency in Pd-catalyzed desymmetric intermolecular C-N coupling under mild conditions with excellent chemo- and enantioselectivity.
具有优势骨架的手性配体的开发在过渡金属催化的不对称反应中起着重要作用。在此，我们展示了一种源自蒽光二聚体的手性单膦配体，其具有双重手性和刚性骨架。该配体在温和条件下的钯催化的非对称分子间碳氮偶联反应中表现出显著的效率，具有出色的化学选择性和对映选择性。
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