Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Tropical Medicine and International Health, Berlin, Germany.
University Teaching Hospital of Butare, Huye, Rwanda.
Antimicrob Agents Chemother. 2021 Aug 17;65(9):e0090121. doi: 10.1128/AAC.00901-21.
Plasmodium falciparum gene () polymorphisms associate with altered antimalarial susceptibility. Between 2010 and 2018/2019, we observed that the prevalence of the wild-type allele N86 and the wild-type combination NYD increased 10-fold (4% versus 40%) and more than 2-fold (18% versus 44%), respectively. Haplotypes other than NYD or NFD declined by up to >90%. Our molecular data suggest the pattern shifted toward one associated with artemether-lumefantrine resistance.
恶性疟原虫基因（）多态性与抗疟药物敏感性改变相关。在 2010 年至 2018/2019 年期间，我们观察到野生型等位基因 N86 和野生型组合 NYD 的流行率增加了 10 倍（4%对 40%）和两倍以上（18%对 44%）。除 NYD 或 NFD 以外的单倍型下降了高达>90%。我们的分子数据表明，这种模式向与青蒿琥酯-咯萘啶耐药相关的模式转变。
