Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Department of Ophthalmology, University of Texas McGovern Medical School, Houston, Texas, USA.
Ocul Immunol Inflamm. 2021 Aug 18;29(6):1190-1199. doi: 10.1080/09273948.2021.1939390. Epub 2021 Jul 6.
Graft-versus-host disease is a common complication following allogeneic hematopoetic stem cell transplantation that can affect multiple organ systems, including the eyes. Ocular GVHD (oGVHD) is characterized by a T cell-mediated immune response that leads to immune cell infiltration and inflammation of ocular structures, including the lacrimal glands, eyelids, cornea and conjunctiva. oGVHD has a significant negative impact on visual function and quality of life and successful management requires a multi-disciplinary approach with frequent monitoring. Here, we review the pathophysiology and clinical presentation of oGVHD, along with current therapeutic strategies based on our clinical experience and the reported literature.
移植物抗宿主病是异基因造血干细胞移植后的一种常见并发症，可影响多个器官系统，包括眼睛。眼部移植物抗宿主病（oGVHD）的特征是 T 细胞介导的免疫反应，导致免疫细胞浸润和眼部结构的炎症，包括泪腺、眼睑、角膜和结膜。oGVHD 对视觉功能和生活质量有显著的负面影响，成功的管理需要多学科的方法和频繁的监测。在这里，我们根据我们的临床经验和报告的文献，回顾了 oGVHD 的病理生理学和临床表现，以及当前的治疗策略。
