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严重急性呼吸综合征冠状病毒2(SARS-CoV2)感染后双侧发热后视网膜病变伴视网膜血管阻塞

Bilateral Post Fever Retinitis With Retinal Vascular Occlusions Following Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV2) Infection.

作者信息

Mahendradas Padmamalini, Hande Prathibha, Patil Aditya, Kawali Ankush, Sanjay Srinivasan, Ahmed Syed Asrar, Thomas Sherina, Shetty Rohit

机构信息

Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India.

Department of Vitreo Retina, Narayana Nethralaya, Bangalore, India.

出版信息

Ocul Immunol Inflamm. 2022 Oct-Nov;30(7-8):1715-1720. doi: 10.1080/09273948.2021.1936564. Epub 2021 Jul 6.

DOI:10.1080/09273948.2021.1936564
PMID:34228600
Abstract

INTRODUCTION

As the world fights the pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), several reports of retinal manifestations of the disease are emerging. Post fever retinitis is a well reported ocular inflammatory reaction to multiple invasive agents, be it virus, bacteria or other microbial agent.

PURPOSE

We report an interesting case of bilateral multifocal retinitis with multiple vascular occlusions in a patient, three weeks after a febrile illness.

RESULTS

Investigations to ascertain the cause of fever resulted in identifying ephemeral seropositivity for several different Ribonucleic acid (RNA) viruses. The retinitis was managed with systemic steroids, doxycycline and anticoagulants with improvement in vision.

CONCLUSION

High and persistent seropositive response against (SARS-CoV-2) helped us to narrow it as the causative agent but the cross reactivity of SARS-CoV-2 with other viruses can be misleading and needs careful interpretation.

摘要

引言

在全球抗击由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的大流行之际,关于该疾病视网膜表现的几份报告不断涌现。发热后视网膜炎是一种已被充分报道的针对多种侵袭性病原体(无论是病毒、细菌还是其他微生物病原体)的眼部炎症反应。

目的

我们报告一例发热性疾病三周后出现双侧多灶性视网膜炎并伴有多处血管阻塞的有趣病例。

结果

为确定发热原因所做的检查发现,患者对几种不同的核糖核酸(RNA)病毒呈短暂血清学阳性。视网膜炎采用全身用类固醇、多西环素和抗凝剂进行治疗,视力有所改善。

结论

针对(SARS-CoV-2)的高持续性血清学阳性反应帮助我们将其确定为病原体,但SARS-CoV-2与其他病毒的交叉反应可能会产生误导,需要仔细解读。

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