Department of Anatomy and Neurobiology, Virginia Commonwealth University, 1101 East Marshall Street, Box 980709, Richmond, VA 23298, United States.
Department of Anatomy and Neurobiology, Virginia Commonwealth University, 1101 East Marshall Street, Box 980709, Richmond, VA 23298, United States.
Physiol Behav. 2021 Oct 1;239:113523. doi: 10.1016/j.physbeh.2021.113523. Epub 2021 Jul 3.
The hormones estrogen and progesterone alter physiological functions, including the estrus cycle and relevant neurological and synaptic activity. Here, we determined the extent to which estrus cycle stage interacts with an inflammatory stimulus, lipopolysaccharide (LPS), to alter synaptic mitochondrial respiration in female rats. LPS elevated synaptic mitochondrial respiration of rats in estrus, but not diestrus. Likewise, estrogen concentration correlated with multiple respiratory metrics in LPS treated females in estrus. These data suggest estrogen likely modulates synaptic mitochondrial respiration in a high progesterone environment.
雌激素和孕激素改变生理功能，包括发情周期和相关的神经和突触活动。在这里，我们确定发情周期阶段与炎症刺激物脂多糖（LPS）相互作用的程度，以改变雌性大鼠的突触线粒体呼吸。LPS 提高了发情期大鼠的突触线粒体呼吸，但不在动情后期。同样，在发情期接受 LPS 处理的雌性动物中，雌激素浓度与多种呼吸指标相关。这些数据表明，雌激素可能在高孕激素环境中调节突触线粒体呼吸。
