Czech University of Life Sciences Prague, Faculty of Agrobiology, Food and Natural Resources, Department of Zoology and Fisheries, Kamýcká 129, 165 00 Prague 6, Czech Republic.
University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25 Vodňany, Czech Republic.
J Exp Biol. 2021 Jul 1;224(13). doi: 10.1242/jeb.242145. Epub 2021 Jul 6.
Illicit drug abuse presents pervasive adverse consequences for human societies around the world. Illicit drug consumption also plays an unexpected role in contamination of aquatic ecosystems that receive wastewater discharges. Here, we show that methamphetamine, considered as one of the most important global health threats, causes addiction and behavior alteration of brown trout Salmo trutta at environmentally relevant concentrations (1 µg l-1). Altered movement behavior and preference for methamphetamine during withdrawal were linked to drug residues in fish brain tissues and accompanied by brain metabolome changes. Our results suggest that emission of illicit drugs into freshwater ecosystems causes addiction in fish and modifies habitat preferences with unexpected adverse consequences of relevance at the individual and population levels. As such, our study identifies transmission of human societal problems to aquatic ecosystems.
非法药物滥用对全球人类社会造成了普遍的不良后果。非法药物的使用也在受废水排放影响的水生生态系统污染中扮演了意料之外的角色。在这里，我们表明，作为最重要的全球健康威胁之一的甲基苯丙胺，会以环境相关浓度（1μg/L）导致褐鳟 Salmo trutta 上瘾和行为改变。在戒断期间，运动行为的改变和对甲基苯丙胺的偏好与鱼脑组织中的药物残留有关，并伴有大脑代谢组的变化。我们的研究结果表明，将非法药物排放到淡水生态系统中会导致鱼类上瘾，并改变其栖息地偏好，从而对个体和种群水平产生意想不到的负面影响。因此，我们的研究确定了人类社会问题向水生生态系统的传播。
