Zheng Qiuda, Ren Yuan, Wang Zhe, Liu Jinhua, Zhang Yu, Lin Wenting, Gao Jianfa, Thomas Kevin V, Thai Phong K
Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba 4102, Queensland, Australia.
School of Environment and Energy, South China University of Technology, Higher Education Mega Center, Panyu District, Guangzhou 510006, China.
J Hazard Mater. 2021 Sep 5;417:125999. doi: 10.1016/j.jhazmat.2021.125999. Epub 2021 May 6.
Wastewater-based epidemiology (WBE) has been used extensively around the globe to provide information on illicit drug consumption. In China, most WBE studies to date only include a limited number of samples per catchment, making it difficult to derive any temporal consumption patterns. This study addresses this knowledge gap by identifying the temporal consumption trends of nine drugs in a Chinese megacity using WBE over a one-year period. Daily influent samples (n = 279) were collected from a wastewater treatment plant serving ~500,000 residents. All target drugs showed similar levels of consumption throughout the week. These findings were different to previous WBE studies in developed countries, where amphetamine-type drugs have shown higher consumption on weekends than during the week. Such a difference could be due to the users' demographics and behaviors as reported in previous surveys and warrant more research to help formulate appropriate drug control policies in China. Our study also observed that declining methamphetamine and ketamine consumption between 2012 and 2018, while consumption of MDMA and methadone were stable over the same period.
基于废水的流行病学（WBE）已在全球广泛用于提供有关非法药物消费的信息。在中国，迄今为止，大多数基于废水的流行病学研究每个集水区仅包括有限数量的样本，因此难以得出任何时间上的消费模式。本研究通过使用WBE在一年时间内确定中国一个特大城市中九种药物的时间消费趋势来填补这一知识空白。从一个为约50万居民服务的污水处理厂收集了每日进水样本（n = 279）。所有目标药物在一周内的消费水平相似。这些发现与发达国家先前的基于废水的流行病学研究不同，在发达国家，苯丙胺类药物在周末的消费量高于工作日。这种差异可能归因于先前调查中报告的使用者的人口统计学特征和行为，需要更多研究以帮助制定中国适当的药物管制政策。我们的研究还观察到，2012年至2018年间甲基苯丙胺和氯胺酮的消费量下降，而同期摇头丸和美沙酮的消费量保持稳定。
