Department of Emergency, The First Hospital of Jilin University, Changchun, Jilin, China.
Department of Pathology, China-Japan Friendship Hospital, Beijing, China.
Cell Cycle. 2021 Aug;20(15):1468-1476. doi: 10.1080/15384101.2021.1949840. Epub 2021 Jul 7.
Evidence has demonstrated that miRNAs play an irreplaceable role in tumorigenesis and progression of a broad range of cancers, including gastric cancer. Among these miRNAs, miR-10a and miR-10b have been identified to critically participate in gastric carcinogenesis and malignant progression. In this review, we briefly describe the role of miR-10a and miR-10b in gastric cancer, especially in the regulation of cell proliferation, apoptosis, cell cycle, migration, invasion and metastasis, drug resistance, and cancer stem cells. Furthermore, we highlight several compounds that target the miR-10 family and exhibit antitumor activity in cancer cells. Moreover, we conclude that targeting the miR-10 family might be a promising approach for the treatment of gastric cancer.
有证据表明，miRNAs 在多种癌症（包括胃癌）的发生和进展中发挥着不可替代的作用。在这些 miRNAs 中，miR-10a 和 miR-10b 被确定为在胃癌发生和恶性进展中起关键作用。在这篇综述中，我们简要描述了 miR-10a 和 miR-10b 在胃癌中的作用，特别是在调节细胞增殖、凋亡、细胞周期、迁移、侵袭和转移、耐药性和癌症干细胞方面的作用。此外，我们还强调了几种针对 miR-10 家族并在癌细胞中表现出抗肿瘤活性的化合物。此外，我们得出结论，针对 miR-10 家族可能是治疗胃癌的一种有前途的方法。
