Giuppi Martina, La Salvia Anna, Evangelista Jessica, Ghidini Michele
Faculty of Medicine, CEU San Pablo University, 28003 Madrid, Spain.
Department of Oncology, University Hospital 12 de Octubre, 28041 Madrid, Spain.
Biology (Basel). 2021 Feb 12;10(2):146. doi: 10.3390/biology10020146.
Gastric cancer (GC) is the fifth most frequently diagnosed malignant tumor and the third highest cause of cancer mortality worldwide. For advanced GC, many novel drugs and combinations have been tested, but results are still disappointing, and the disease is incurable in the majority of cases. In this regard, it is critical to investigate the molecular mechanisms underlying GC development. Angiogenesis is one of the hallmarks of cancer with a fundamental role in GC growth and progression. Ramucirumab, a monoclonal antibody that binds to vascular endothelial growth factor-2 (VEGFR-2), is approved in the treatment of advanced and pretreated GC. However, no predictive biomarkers for ramucirumab have been identified so far. Micro RNAs (miRNAs) are a class of evolutionarily-conserved single-stranded non-coding RNAs that play an important role (via post-transcriptional regulation) in essentially all biologic processes, such as cell proliferation, differentiation, apoptosis, survival, invasion, and migration. In our review, we aimed to analyze the available data on the role of angiogenesis-related miRNAs in GC.
胃癌（GC）是全球第五大最常被诊断出的恶性肿瘤，也是癌症死亡的第三大原因。对于晚期胃癌，许多新型药物及其联合用药都已进行了试验，但结果仍然令人失望，并且在大多数情况下该疾病无法治愈。在这方面，研究胃癌发生发展的分子机制至关重要。血管生成是癌症的标志之一，在胃癌的生长和进展中起着重要作用。雷莫西尤单抗是一种与血管内皮生长因子-2（VEGFR-2）结合的单克隆抗体，已被批准用于治疗晚期和经预处理的胃癌。然而，迄今为止尚未发现雷莫西尤单抗的预测性生物标志物。微小RNA（miRNA）是一类进化上保守的单链非编码RNA，在基本上所有生物学过程（如细胞增殖、分化、凋亡、存活、侵袭和迁移）中（通过转录后调控）发挥重要作用。在我们的综述中，我们旨在分析血管生成相关miRNA在胃癌中作用的现有数据。
