Phase Behavior of Polyglycerol Ester-Based Nanoemulsions.

Nanoemulsions were prepared using polyglycerol esters as emulsifiers. The effects of emulsifiers, oils, and polyols on the phase behavior of nanoemulsions were analyzed by phase diagram method using caprylic acid capric triglyceride (318), mineral oil, and squalane (Squ) as oils respectively. Various factors affecting the area of the oil-in-water (O/W) nanoemulsion were investigated. The results showed that hydrophilic polyglyceryl-4 laurate was beneficial to the formation of translucent nanoemulsions, while lipophilic polyglyceryl-4 oleate could synergize the emulsification performance and was more conducive to the formation of nanoemulsions; the type of oil could affect the emulsifying ability of the emulsifier. It was found that it was beneficial to form translucent nanoemulsion when caprylic acid capric triglyceride was adopted as oil. However, it was almost impossible to form translucent nanoemulsions when mineral oil and squalane were used as oils. The addition of water-soluble jojoba ester was beneficial to the formation of O/W emulsion. In addition, glycerin can improve the polarity of the aqueous medium, enhance the affinity between emulsifiers and aqueous medium, and help to form a translucent nanoemulsion.