内镜活检中来自炎症性肠病瑞典患者的非对称分裂隐窝

Crypts in Asymmetric Fission in Endoscopic Biopsies from Swedish Patients With Inflammatory Bowel Disease.

机构信息

Gastrointestinal Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden;

Department of Medicine (Solna), Karolinska Institute and Ersta Hospital, Stockholm, Sweden.

出版信息

Anticancer Res. 2021 Jul;41(7):3511-3517. doi: 10.21873/anticanres.15138.

DOI:10.21873/anticanres.15138

PMID:34230146

Abstract

BACKGROUND/AIM: We previously found crypts in symmetric fission (CSF) and in asymmetric fission (CAF) in colectomy-specimens with ulcerative colitis. We now analyzed CSF and CAF (CSAF) in biopsies from 80 patients with inflammatory bowel disease (IBD) without dysplasia or carcinoma.

PATIENTS AND METHODS

One unselected double-biopsy from affected endoscopic areas was investigated in the 80 cases.

RESULTS

A total of 353 crypts in fission were found. The median number of CAF/biopsy was 3.7 and for CSF/biopsy, 0.7 (p<0.00001).

CONCLUSION

CSAF often occur in unselected biopsies from patients with IBD. Whereas the increased frequency of CSF might mirror a compensatory mechanism of crypt production in areas occupied by inflammation, CAF reflects a pathological aberration of cryptogenesis, probably generated by somatic mutations. The biological significance of CAF in IBD without dysplasia or carcinoma, deserves to be further investigated.

摘要

背景/目的：我们之前在溃疡性结肠炎的结肠切除术标本中发现了对称分裂（CSF）和不对称分裂（CAF）中的隐窝。现在，我们分析了 80 例无发育不良或癌的炎症性肠病（IBD）患者的活检中的 CSF 和 CAF（CSAF）。