Gastrointestinal Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden;
Department of Medicine (Solna), Karolinska Institute and Ersta Hospital, Stockholm, Sweden.
Anticancer Res. 2021 Jul;41(7):3511-3517. doi: 10.21873/anticanres.15138.
BACKGROUND/AIM: We previously found crypts in symmetric fission (CSF) and in asymmetric fission (CAF) in colectomy-specimens with ulcerative colitis. We now analyzed CSF and CAF (CSAF) in biopsies from 80 patients with inflammatory bowel disease (IBD) without dysplasia or carcinoma.
One unselected double-biopsy from affected endoscopic areas was investigated in the 80 cases.
A total of 353 crypts in fission were found. The median number of CAF/biopsy was 3.7 and for CSF/biopsy, 0.7 (p<0.00001).
CSAF often occur in unselected biopsies from patients with IBD. Whereas the increased frequency of CSF might mirror a compensatory mechanism of crypt production in areas occupied by inflammation, CAF reflects a pathological aberration of cryptogenesis, probably generated by somatic mutations. The biological significance of CAF in IBD without dysplasia or carcinoma, deserves to be further investigated.
背景/目的：我们之前在溃疡性结肠炎的结肠切除术标本中发现了对称分裂（CSF）和不对称分裂（CAF）中的隐窝。现在，我们分析了 80 例无发育不良或癌的炎症性肠病（IBD）患者的活检中的 CSF 和 CAF（CSAF）。
在这 80 例患者中，我们对受累内镜区域的 1 个未选择的双活检进行了研究。
总共发现了 353 个分裂隐窝。CAF/活检的中位数为 3.7，CSF/活检的中位数为 0.7（p<0.00001）。
CSAF 在 IBD 患者的未选择活检中经常发生。虽然 CSF 频率的增加可能反映了炎症部位的隐窝生成的补偿机制，但 CAF 反映了隐窝发生的病理性异常，可能是由体细胞突变产生的。在无发育不良或癌的 IBD 中，CAF 的生物学意义值得进一步研究。
