Rubio Carlos, Lang-Schwarz Corinna, Vieth Michael
Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden.
Institute of Pathology, Friedrich-Alexander University Erlangen-Nuremberg, Klinikum Bayreuth, Bayreuth, Germany.
Cancer Diagn Progn. 2023 May 3;3(3):334-337. doi: 10.21873/cdp.10220. eCollection 2023 May-Jun.
BACKGROUND/AIM: For many years, it was empirically estimated that the majority of the routine colon biopsies in Swedish patients with ulcerative colitis (UC), exhibited cross-cut crypts. The aim of the present study was to assess the frequency of cross-cut crypts (CCC) and well-oriented crypts in routine colon biopsies in German patients with UC.
In total, 447 colon biopsies: 376 with UC and 71 controls were investigated.
Out of 376 colon biopsies with UC, 73% exhibited ≥60% CCC. Out of the 237 biopsies showing ≥80% CCC, as many as 71% exhibited 100% CCC in individual biopsies. Similar percentages were found in control biopsies.
The majority of the routine colon biopsies with UC, as well as control biopsies in German patients displayed CCC. Thus, an unnoticed, consequent, and systematic cutting technical hitch was introduced during the laboratory processing of colon biopsies. The reason(s) behind the similar histologic processing mode of colon biopsies at the two geographically disparate laboratories (Sweden and Germany) remains elusive. The cross-cutting mode influenced the narrative of biopsies in UC, inasmuch as some histological parameters listed among well-oriented colon sections were not present in sections displaying CCC.
背景/目的：多年来，根据经验估计，瑞典溃疡性结肠炎（UC）患者的大多数常规结肠活检标本显示有横切隐窝。本研究的目的是评估德国UC患者常规结肠活检标本中横切隐窝（CCC）和取向良好的隐窝的频率。
共调查了447份结肠活检标本，其中376份来自UC患者，71份为对照。
在376份UC患者的结肠活检标本中，73%显示CCC≥60%。在237份显示CCC≥80%的活检标本中，多达71%的单个活检标本显示CCC为100%。对照活检标本中也发现了类似的百分比。
德国UC患者的大多数常规结肠活检标本以及对照活检标本均显示有CCC。因此，在结肠活检标本的实验室处理过程中引入了一个未被注意到的、一致的和系统性的切割技术问题。在两个地理位置不同的实验室（瑞典和德国），结肠活检标本采用相似的组织学处理方式的原因仍不清楚。横切方式影响了UC活检的描述，因为在显示CCC的切片中不存在一些在取向良好的结肠切片中列出的组织学参数。
