Saeed M, Hartmann A, Bing R J
Huntington Medical Research Institutes, Pasadena, Calif.
Pharmacology. 1987;35(5):256-63. doi: 10.1159/000138318.
The effect of nisoldipine on coronary vascular resistances, cardiac performance and myocardial oxygen consumption was determined. Rabbit hearts were perfused with a perfluorochemical (FC-43) emulsion. Endothelium was removed from the obtuse marginal and the upper portion of the anterior descending coronary artery. Changes in the internal diameter of these arteries were visualized using injection of Patent Blue Dye (color arteriography). Mean internal diameter of coronary arteries and surface area/unit length were computer calculated. Nisoldipine reduced the constriction of coronary arteries and the decrease on coronary flow induced by histamine. Nisoldipine abolished or reduced the decrease in cardiac output, LVESP, dP/dt and myocardial oxygen consumption. The results demonstrate that in the supported rabbit heart preparation, nisoldipine is an effective dilator of large subepicardial coronary arteries, deprived of endothelial lining, and counteracts constriction of coronary resistance vessels. As a consequence nisoldipine improves performance of the ischemic myocardium.
研究了尼索地平对冠状动脉阻力、心脏功能和心肌耗氧量的影响。用全氟化合物（FC - 43）乳剂灌注兔心脏。去除钝缘支和冠状动脉前降支上段的内皮。通过注射专利蓝染料（彩色动脉造影）观察这些动脉内径的变化。计算机计算冠状动脉的平均内径和单位长度表面积。尼索地平可减轻组胺诱导的冠状动脉收缩和冠状动脉血流减少。尼索地平消除或减轻了心输出量、左心室收缩末期压、dp/dt和心肌耗氧量的降低。结果表明，在支持的兔心脏制备中，尼索地平是大的心外膜下冠状动脉（无内皮）的有效扩张剂，并可对抗冠状动脉阻力血管的收缩。因此，尼索地平可改善缺血心肌的功能。
