Inner Mongolia Laboratory of Molecular Biology, Inner Mongolia Medical University, Jinshan Avenue, Jinshan Development Zone, Hohhot, 010059, Inner Mongolia Autonomous Region, China.
WHO WPRO Regional Reference Measles/Rubella Laboratory, NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention), 155# Changbai Road, Changping District, Beijing, 102200, China.
Arch Virol. 2021 Sep;166(9):2585-2590. doi: 10.1007/s00705-021-05154-3. Epub 2021 Jul 6.
During 2017-2018, nasopharyngeal aspirates (NPAs) from 627 hospitalized patients with severe acute respiratory infection at Luohe Center Hospital were tested by RT-PCR for human parainfluenza virus 4 (HPIV-4). Fourteen (2.2%) of the 627 samples were positive for HPIV-4. The complete HN gene was amplified from nine positive samples and sequenced. Sequence comparisons showed that the HPIV-4 strains circulating in the city of Luohe are closely related to HPIV-4A strains. Our study indicated that there were multiple lineages of HPIV-4 circulating in Henan Province in China during the study period. This will improve our understanding of the epidemiological and clinical characteristics of HPIV-4.
在 2017-2018 年期间，漯河市中心医院对 627 例住院严重急性呼吸道感染患者的鼻咽抽吸物（NPAs）进行了人副流感病毒 4（HPIV-4）的 RT-PCR 检测。627 个样本中，有 14 个（2.2%）为 HPIV-4 阳性。从 9 个阳性样本中扩增了完整的 HN 基因并进行了测序。序列比较表明，漯河市流行的 HPIV-4 株与 HPIV-4A 株密切相关。本研究表明，研究期间中国河南省存在多种 HPIV-4 谱系。这将有助于我们了解 HPIV-4 的流行病学和临床特征。
