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预测初次髋关节镜治疗股骨髋臼撞击综合征前后续髋关节手术的风险:髋关节保留术前危险因素的机器学习分析

Predicting the Risk of Subsequent Hip Surgery Before Primary Hip Arthroscopy for Femoroacetabular Impingement Syndrome: A Machine Learning Analysis of Preoperative Risk Factors in Hip Preservation.

作者信息

Haeberle Heather S, Ramkumar Prem N, Karnuta Jaret M, Sullivan Spencer, Sink Ernest L, Kelly Bryan T, Ranawat Anil S, Nwachukwu Benedict U

机构信息

Orthopaedic Machine Learning Laboratory, Cleveland Clinic, Cleveland, Ohio, USA.

Sports Medicine & Hip Preservation Service, Hospital for Special Surgery, New York, New York, USA.

出版信息

Am J Sports Med. 2021 Aug;49(10):2668-2676. doi: 10.1177/03635465211024964. Epub 2021 Jul 7.

Abstract

BACKGROUND

The number of patients requiring reoperation has increased as the volume of hip arthroscopy for femoroacetabular impingement syndrome (FAIS) has increased. The factors most important in determining patients who are likely to require reoperation remain elusive.

PURPOSE

To leverage machine learning to better characterize the complex relationship across various preoperative factors (patient characteristics, radiographic parameters, patient-reported outcome measures [PROMs]) for patients undergoing primary hip arthroscopy for FAIS to determine which features predict the need for future ipsilateral hip reoperation, namely, revision hip arthroscopy, total hip arthroplasty (THA), hip resurfacing arthroplasty (HRA), or periacetabular osteotomy (PAO).

STUDY DESIGN

Cohort study; Level of evidence, 3.

METHODS

A cohort of 3147 patients undergoing 3748 primary hip arthroscopy procedures were included from an institutional hip preservation registry. Preoperative computed tomography of the hip was obtained for each patient, from which the following parameters were calculated: the alpha angle; the coronal center-edge angle; the neck-shaft angle; the acetabular version angle at 1, 2, and 3 o'clock; and the femoral version angle. Preoperative PROMs included the modified Harris Hip Score (mHHS), the Hip Outcome Score (HOS)-Activities of Daily Living subscale (HOS-ADL) and the Sport Specific subscale, and the international Hip Outcome Tool (iHOT-33). Random forest models were created for revision hip arthroscopy, the THA, the HRA, and the PAO. Area under the curve (AUC) for the receiver operating characteristic curve and accuracy were calculated to evaluate each model.

RESULTS

A total of 171 patients (4.6%) underwent subsequent hip surgery after primary hip arthroscopy for FAIS. The AUC and accuracy, respectively, were 0.77 (fair) and 76% for revision hip arthroscopy (mean, 26.4-month follow-up); 0.80 (good) and 81% for THA (mean, 32.5-month follow-up); 0.62 (poor) and 69% for HRA (mean, 45.4-month follow-up); and 0.76 (fair) and 74% for PAO (mean, 30.4-month follow-up). The most important factors in predicting reoperation after primary hip arthroscopy were higher body mass index (BMI) and lower preoperative HOS-ADL for revision hip arthroscopy, greater age and lower preoperative iHOT-33 for THA, increased BMI for HRA, and larger neck-shaft angle and lower preoperative mHHS for PAO.

CONCLUSION

Despite the low failure rate of hip arthroscopy for FAIS, our study demonstrated that machine learning has the capability to identify key preoperative risk factors that may predict subsequent ipsilateral hip surgery before the index hip arthroscopy. Knowledge of these demographic, radiographic, and patient-reported outcome data may aid in preoperative counseling and expectation management to better optimize hip preservation.

摘要

背景

随着针对股骨髋臼撞击综合征(FAIS)的髋关节镜手术量增加,需要再次手术的患者数量也在上升。确定哪些患者可能需要再次手术的最重要因素仍不明确。

目的

利用机器学习更好地描述接受初次FAIS髋关节镜手术患者的各种术前因素(患者特征、影像学参数、患者报告结局量表[PROMs])之间的复杂关系,以确定哪些特征可预测未来同侧髋关节再次手术的需求,即翻修髋关节镜手术、全髋关节置换术(THA)、髋关节表面置换术(HRA)或髋臼周围截骨术(PAO)。

研究设计

队列研究;证据等级,3级。

方法

从机构性髋关节保留登记处纳入3147例接受3748例初次髋关节镜手术的患者队列。为每位患者进行术前髋关节计算机断层扫描,并计算以下参数:α角、冠状面中心边缘角、颈干角、1点、2点和3点位置的髋臼旋转角以及股骨旋转角。术前PROMs包括改良Harris髋关节评分(mHHS)、髋关节结局评分(HOS)-日常生活活动分量表(HOS-ADL)和运动特定分量表以及国际髋关节结局工具(iHOT-33)。针对翻修髋关节镜手术、THA、HRA和PAO创建随机森林模型。计算受试者工作特征曲线的曲线下面积(AUC)和准确性以评估每个模型。

结果

共有171例患者(4.6%)在初次FAIS髋关节镜手术后接受了后续髋关节手术。翻修髋关节镜手术(平均随访26.4个月)的AUC和准确性分别为0.77(一般)和76%;THA(平均随访32.5个月)为0.80(良好)和81%;HRA(平均随访45.4个月)为0.62(较差)和69%;PAO(平均随访30.4个月)为0.76(一般)和74%。预测初次髋关节镜手术后再次手术的最重要因素是:翻修髋关节镜手术时较高的体重指数(BMI)和较低的术前HOS-ADL;THA时较大的年龄和较低的术前iHOT-33;HRA时升高的BMI;PAO时较大的颈干角和较低的术前mHHS。

结论

尽管FAIS髋关节镜手术的失败率较低,但我们的研究表明,机器学习有能力识别关键的术前风险因素,这些因素可能在初次髋关节镜手术前预测后续同侧髋关节手术。了解这些人口统计学、影像学和患者报告结局数据可能有助于术前咨询和预期管理,以更好地优化髋关节保留。

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