Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, 7030 Trondheim, Norway.
School of Biological Sciences, Nanyang Technological University, Singapore 308232, Singapore.
Cell Rep. 2021 Jul 6;36(1):109324. doi: 10.1016/j.celrep.2021.109324.
Adult neurogenesis in the dentate gyrus plays a role in adaptive brain functions such as memory formation. Adding new neurons to a specific locus of a neural circuit with functional needs is an efficient way to achieve such an adaptive function. However, it is unknown whether neurogenesis is linked to local functional demands potentially specified by the activity of neuronal circuits. By examining the distribution of neurogenesis and different types of neuronal activity in the dentate gyrus of freely moving adult rats, we find that neurogenesis is positionally associated with active excitatory neurons, some of which show place-cell activity, but is positionally dissociated from a type of interneuron with high-burst tendency. Our finding suggests that the behaviorally relevant activity of excitatory-inhibitory neuronal circuits can define a microenvironment stimulating/inhibiting neurogenesis. Such local regulation of neurogenesis may contribute to strategic recruitment of new neurons to modify functionally relevant neural circuits.
成人海马中的神经发生在记忆形成等适应性脑功能中发挥作用。为了实现这种适应性功能，向具有功能需求的神经回路的特定位置添加新神经元是一种有效的方法。然而，目前尚不清楚神经发生是否与神经元回路活动潜在指定的局部功能需求有关。通过检查在自由活动的成年大鼠的海马中的神经发生和不同类型的神经元活动的分布，我们发现神经发生与活跃的兴奋性神经元在位置上相关联，其中一些神经元表现出位置细胞活性，但与具有高爆发倾向的一种中间神经元在位置上分离。我们的发现表明，兴奋性-抑制性神经元回路的与行为相关的活动可以定义一个刺激/抑制神经发生的微环境。这种神经发生的局部调节可能有助于新神经元的战略募集，以修改功能相关的神经回路。
