Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Pharmacology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Neurosci Lett. 2022 Jan 1;766:136343. doi: 10.1016/j.neulet.2021.136343. Epub 2021 Nov 11.
The adult dentate gyrus (DG) of the hippocampal formation is a specialized region of the brain that creates new adult-born neurons from a pool of resident adult neural stem and progenitor cells (aNSPCs) throughout life. These aNSPCs undergo epigenetic and epitranscriptomic regulation, including 3D genome interactions, histone modifications, DNA modifications, noncoding RNA mechanisms, and RNA modifications, to precisely control the neurogenic process. Furthermore, the specialized neurogenic niche also uses epigenetic mechanisms in mature neurons and glial cells to communicate signals to direct the behavior of the aNSPCs. Here, we review recent advances of epigenetic regulation in aNSPCs and their surrounding niche cells within the adult DG.
成人海马齿状回（DG）是大脑的一个特殊区域，它通过一生中驻留的成年神经干细胞和祖细胞（aNSPCs）池产生新的成年出生神经元。这些 aNSPCs 经历表观遗传和转录后修饰调节，包括 3D 基因组相互作用、组蛋白修饰、DNA 修饰、非编码 RNA 机制和 RNA 修饰，以精确控制神经发生过程。此外，专门的神经发生龛还利用成熟神经元和神经胶质细胞中的表观遗传机制来传递信号，以指导 aNSPCs 的行为。在这里，我们综述了成人 DG 中 aNSPCs 及其周围龛细胞的表观遗传调控的最新进展。
