Department of Ophthalmology, 2nd Hospital of Jilin University, Changchun 130041, China.
Norman Bethune Health Science Center of Jilin University, Changchun 130021, China.
Exp Biol Med (Maywood). 2021 Nov;246(21):2269-2277. doi: 10.1177/15353702211028193. Epub 2021 Jul 7.
Epithelial tissue has important functions such as protection, secretion, and sensation. Epithelial damage is involved in various pathological processes. Bone morphogenetic proteins (BMPs) are a class of growth factors with multiple functions. They play important roles in epithelial cells, including in differentiation, proliferation, and migration during the repair of the epithelium. This article reviews the functions and mechanisms of the most profoundly studied BMPs in the process of epithelial damage repair and their clinical significance.
上皮组织具有保护、分泌和感觉等重要功能。上皮损伤涉及多种病理过程。骨形态发生蛋白（BMPs）是一类具有多种功能的生长因子。它们在上皮细胞中发挥重要作用，包括在修复上皮过程中的分化、增殖和迁移。本文综述了研究最深入的 BMPs 在上皮损伤修复过程中的功能和机制及其临床意义。
