12250Indiana University School of Medicine, Indianapolis, IN, USA.
College of Health Sciences, School of Medicine, Department of Reproductive Health, 107853Moi University, Eldoret, Kenya.
Int J STD AIDS. 2021 Nov;32(13):1212-1220. doi: 10.1177/09564624211030766. Epub 2021 Jul 7.
A longitudinal study was conducted among women living with HIV in Kenya to determine if duration of anti-retroviral (ART) usage altered detection and persistence of oncogenic (high-risk) human papillomaviruses (HR-HPV).
Women living with HIV without cervical dysplasia were enrolled at a cervical cancer screening clinic. Three cervical swabs, HIV viral loads, and CD4 cell counts were obtained at enrollment and at two annual visits. HPV genotyping was performed on swabs (Roche Linear Array). Linear regression models assessed effects of ART duration on HR-HPV detection and persistence.
Seventy-seven women, median age 38 years, completed three study visits and were included in the analysis. The mean time from HIV diagnosis to enrollment was 9.6 years (SD 3.9 years). The mean ART duration was 6.2 years (SD 3.1 years). Most women had undetectable HIV viral loads and CD4 cell counts above 500 cells/L. Each additional year of ART use reduced the likelihood of detection of HR-HPV by 10-15% and persistent detection of A9 HR-HPV by 20%.
Among Kenyan women living with HIV, longer duration of ART use was associated with significantly reduced risk of all detection and persistent detection of HR-HPV.
本纵向研究在肯尼亚 HIV 感染者中进行，旨在确定抗逆转录病毒（ART）治疗的持续时间是否会改变致癌（高危）型人乳头瘤病毒（HR-HPV）的检出和持续存在。
在宫颈癌筛查诊所，招募无宫颈发育不良的 HIV 感染者。在入组时和每两年一次的随访中，采集 3 份宫颈拭子、HIV 病毒载量和 CD4 细胞计数。使用罗氏线性阵列对拭子进行 HPV 基因分型。线性回归模型评估了 ART 持续时间对 HR-HPV 检出和持续存在的影响。
77 名中位年龄为 38 岁的女性完成了三次研究访问并纳入分析。从 HIV 诊断到入组的平均时间为 9.6 年（SD 3.9 年）。ART 持续时间的平均为 6.2 年（SD 3.1 年）。大多数女性的 HIV 病毒载量不可检测，CD4 细胞计数高于 500 个/升。ART 使用每增加 1 年，HR-HPV 的检出率和 A9 HR-HPV 的持续检出率降低 10-15%和 20%。
在肯尼亚 HIV 感染者中，ART 治疗持续时间的延长与 HR-HPV 的所有检出和持续检出风险显著降低相关。
