156288UNC Project-Malawi, Lilongwe, Malawi.
Department of Medicine, 6797University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Int J STD AIDS. 2021 Nov;32(13):1204-1211. doi: 10.1177/09564624211030368. Epub 2021 Jul 7.
Sexually transmitted infections (STIs) remain a public health concern because of their interaction(s) with HIV. In the HPTN 052 study, STIs were evaluated in both HIV-positive index cases and their HIV-negative partners at enrollment and at yearly follow-up visits. Our definition for STI was based on any infection with , syphilis, or We used log-binomial regression models to identify factors associated with prevalent STIs. Generalized estimating equation models with the Poisson distribution were used to compare STI incidence between HIV-positive index cases and HIV-negative partners. 8.1% of the participants had STIs at enrollment. The prevalence of STIs (8.9 vs. 7.2) was higher in HIV-positive index cases than HIV-negative partners. Being female (prevalence ratio (PR) = 1.61; 95% CI: 1.20-2.16) or unmarried (PR = 1.92; 95% CI: 1.17-3.14) was associated with prevalent STIs. Compared to HIV-negative male partners, HIV-positive female index cases had a higher risk of STI acquisition (incidence rate ratio (IRR) = 2.25; 95% CI: 1.70-2.97). While we are implementing HIV prevention interventions for HIV-negative people, we should also intensify targeted STI prevention interventions, especially among HIV-positive women.
性传播感染（STIs）仍然是一个公共卫生关注点，因为它们与 HIV 相互作用。在 HPTN 052 研究中，在入组时和每年的随访访视中，评估了 HIV 阳性病例及其 HIV 阴性伴侣的 STIs。我们的 STI 定义基于任何感染、梅毒或淋病。我们使用对数二项式回归模型来确定与现患 STIs 相关的因素。使用具有泊松分布的广义估计方程模型比较 HIV 阳性病例和 HIV 阴性伴侣之间的 STI 发病率。8.1%的参与者在入组时患有 STIs。与 HIV 阴性伴侣相比，HIV 阳性病例的 STIs 患病率（8.9 比 7.2）更高。女性（患病率比（PR）= 1.61；95%CI：1.20-2.16）或未婚（PR = 1.92；95%CI：1.17-3.14）与现患 STIs 相关。与 HIV 阴性男性伴侣相比，HIV 阳性女性病例的 STI 获得风险更高（发病率比（IRR）= 2.25；95%CI：1.70-2.97）。虽然我们正在为 HIV 阴性人群实施 HIV 预防干预措施，但我们还应加强针对 STI 的预防干预措施，尤其是针对 HIV 阳性女性。
