氟奋乃静和RMI 12330A对茶碱和根皮素诱导的肠道D-半乳糖积累增加的半数抑制浓度（IC50） 。
IC50 of trifluoperazine and RMI 12330A for the theophylline and phloretin-induced increase in intestinal D-galactose accumulation.
作者信息
Alcalde A I, Barcina Y, Larralde J, Ilundain A
机构信息
Departamento de Fisiología Animal, Universidad de Navarra, Pamplona (Spain).
出版信息
Rev Esp Fisiol. 1987 Sep;43(3):371-4.
PMID:3423397
Abstract
The effect of trifluoperazine and RMI 12330A on D-Galactose accumulation was studied in isolated rat intestinal mucosa. Both drugs inhibited the theophylline and phloretin-induced increase in tissue sugar accumulation in a concentration-dependent fashion, with IC50 values close to 10(-6) M. These findings suggest that calmodulin might mediate the theophylline and phloretin actions on galactose transport in intact rat ileum.
摘要
在离体大鼠肠黏膜中研究了三氟拉嗪和RMI 12330A对D-半乳糖蓄积的影响。两种药物均以浓度依赖方式抑制茶碱和根皮素诱导的组织糖蓄积增加，IC50值接近10^(-6)M。这些发现提示钙调蛋白可能介导茶碱和根皮素对完整大鼠回肠半乳糖转运的作用。
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