水样眼生活质量（WEQOL）问卷：一种用于手术可治疗溢泪症的患者报告结局测量工具。

The watery eye quality of life (WEQOL) questionnaire: a patient-reported outcome measure for surgically amenable epiphora.

机构信息

Department of Ophthalmology, Portsmouth Hospitals University NHS Trust, Cosham, Portsmouth, PO6 3LY, UK.

Corneoplastic Unit, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, RH19 3DZ, UK.

出版信息

Eye (Lond). 2022 Jul;36(7):1468-1475. doi: 10.1038/s41433-021-01674-z. Epub 2021 Jul 7.

DOI:10.1038/s41433-021-01674-z

PMID:34234292

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9232616/

Abstract

OBJECTIVE OR PURPOSE

To develop and test a patient-reported outcome measure for assessing health-related quality of life (HRQOL) in surgically amenable epiphora.

DESIGN

Questionnaire development and validation study.

PARTICIPANTS

201 patients with a cause of epiphora amenable to surgical intervention, recruited across three independent centres.

METHODS, INTERVENTION OR TESTING: The watery eye quality of life (WEQOL) questionnaire was developed and refined according to defined psychometric standards. Both surgical and non-surgical participants completed WEQOL at baseline and follow-up (>3 months), along with the Lacrimal Symptom Questionnaire (Lac-Q), RAND Short Form Health Survey (SF-36) and Glasgow Benefit Inventory (GBI). Convergent validity of WEQOL was evaluated according to correlation (R > 0.40) with each of these additional tests. Responsiveness of WEQOL to intervention was evaluated according to patient-reported success. Test-retest reliability was assessed by the Bland-Altman method and intraclass correlation (ICC) in a subset of 64 participants at baseline.

MAIN OUTCOME MEASURES

WEQOL construct validity, responsiveness and test-retest reliability.

RESULTS

WEQOL was moderately correlated (R > 0.4) with the Lac-Q and several subscales of the SF-36 (physical role limitation, social, emotional role limitation and emotional well-being). A stronger correlation was found between the change in WEQOL at follow-up and GBI (R = 0.61). An appropriate graded response was found with a significant change in WEQOL score being observed in patients reporting successful (-28%, p < 0.0001) and partially successful surgery (-6%, p = 0.04), but not in those reporting unsuccessful surgery (+2%, p = 0.9). High test-retest reliability was observed (ICC = 0.93).

CONCLUSIONS

The WEQOL questionnaire has been developed systematically according to modern psychometric standards and has been designed to evaluate the quality of life in patients with epiphora that is of a surgically amenable cause. In this study, it has demonstrated appropriate test-retest reliability, responsiveness and construct validity.

摘要

目的

开发并验证一种用于评估手术可治疗的溢泪症相关健康相关生活质量（HRQOL）的患者报告结局（PRO）测量工具。

设计

问卷开发和验证研究。

参与者

招募自三家独立中心的 201 名溢泪症患者，病因适合手术干预。

方法

根据明确的心理测量学标准，开发和完善水样泪液质量问卷（WEQOL）。手术和非手术患者均在基线和随访（>3 个月）时完成 WEQOL 以及泪液症状问卷（Lac-Q）、RAND 短式健康调查问卷（SF-36）和格拉斯哥效益量表（GBI）。根据与其他每项测试的相关性（R>0.40）评估 WEQOL 的聚合效度。根据患者报告的成功率评估 WEQOL 对干预的反应性。在基线时的 64 名参与者的子集中，通过 Bland-Altman 方法和组内相关系数（ICC）评估 WEQOL 的重测信度。

主要结局测量指标

WEQOL 的结构有效性、反应性和重测信度。

结果

WEQOL 与 Lac-Q 以及 SF-36 的几个子量表（身体角色受限、社会、情感角色受限和情感健康）中度相关（R>0.4）。在随访时 WEQOL 的变化与 GBI 的相关性更强（R=0.61）。在报告手术成功（-28%，p<0.0001）和部分成功（-6%，p=0.04）的患者中观察到 WEQOL 评分有显著变化，而在报告手术不成功的患者中（+2%，p=0.9）则没有观察到显著变化，提示存在适当的分级反应。观察到较高的重测信度（ICC=0.93）。