Zhang Hengshuo, Chen Lu, Wang Ziyu, Wang Fuan, Shan Yu, Qi Linzeng, Chen Yunzhen
Department of Spine Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.
J Pain Res. 2021 Jul 1;14:2001-2012. doi: 10.2147/JPR.S313790. eCollection 2021.
To examine the association between single nucleotide polymorphisms (SNPs) rs2228570, rs731236, rs7975232, and rs1544410 and lumbar disc degeneration (LDD) predisposition.
A search strategy was carried out, and the data were extracted after being chosen by the inclusion and exclusion criteria. Pooled odds ratios and 95% confidence intervals were calculated to assess the association between the aforementioned SNPs and LDD under allelic, dominant, recessive, heterozygous, and homozygous genetic models. In addition, a case-control study involving 46 LDD cases and 45 controls was also performed in the analysis to verify the result.
A total of 17 studies were included in this meta-analysis. The pooled results did not show any association between vitamin D receptor (VDR) gene polymorphisms and LDD. But, interestingly, in subgroup analysis, the rs2228570 polymorphism was associated with LDD under the allelic (OR = 0.70, 95% CI = 0.56-0.87, p = 0.002), recessive (OR = 0.60, 95% CI = 0.43-0.84, p = 0.003), and homozygous (OR = 0.47, 95% CI= 0.28-0.79, p = 0.004) genetic models in the Asian population. SNPs rs731236 and rs7975232 still did not show any obvious association. We obtained a similar result from the case-control study: rs2228570 had an obvious relationship with LDD under allelic and homozygous genetic models. At the same time, we found that rs2228570 was also associated with the degree of low back pain (visual analogue scale, VAS score) in LDD population.
SNP rs2228570 was significantly associated with LDD predisposition and the degree of low back pain in the Asian population.
研究单核苷酸多态性（SNP）rs2228570、rs731236、rs7975232和rs1544410与腰椎间盘退变（LDD）易感性之间的关联。
开展检索策略，根据纳入和排除标准筛选后提取数据。计算合并比值比和95%置信区间，以评估上述SNP在等位基因、显性、隐性、杂合子和纯合子遗传模型下与LDD的关联。此外，分析中还进行了一项包含46例LDD病例和45例对照的病例对照研究以验证结果。
本荟萃分析共纳入17项研究。合并结果未显示维生素D受体（VDR）基因多态性与LDD之间存在任何关联。但有趣的是，在亚组分析中，rs2228570多态性在亚洲人群的等位基因（OR = 0.70，95%CI = 0.56 - 0.87，p = 0.002）、隐性（OR = 0.60，95%CI = 0.43 - 0.84，p = 0.003）和纯合子（OR = 0.47，95%CI = 0.28 - 0.79，p = 0.004）遗传模型下与LDD相关。SNP rs731236和rs7975232仍未显示出任何明显关联。我们从病例对照研究中获得了类似结果：rs2228570在等位基因和纯合子遗传模型下与LDD存在明显关联。同时，我们发现rs2228570也与LDD人群的腰痛程度（视觉模拟评分，VAS评分）相关。
SNP rs2228570与亚洲人群的LDD易感性及腰痛程度显著相关。
