轻度认知障碍和痴呆患者中脑缺血与角膜神经损伤及脑萎缩的关联
Association of Cerebral Ischemia With Corneal Nerve Loss and Brain Atrophy in MCI and Dementia.
作者信息
Ponirakis Georgios, Elsotouhy Ahmed, Al Hamad Hanadi, Vattoth Surjith, Petropoulos Ioannis N, Khan Adnan, Gad Hoda, Al-Khayat Fatima, Chandran Mani, Ramadan Marwan, Elorrabi Marwa, Gadelseed Masharig, Tosino Rhia, Gawhale Priya V, Alobaidi Maryam, Khan Shafi, Manikoth Pravija, Abdelrahim Yasmin H M, Thodi Noushad, Almuhannadi Hamad, Al-Mohannadi Salma, AlMarri Fatema, Qazi Murtaza, Own Ahmed, Mahfoud Ziyad R, Shuaib Ashfaq, Malik Rayaz A
机构信息
Department of Medicine, Weill Cornell Medicine-Qatar, Qatar Foundation, Doha, Qatar.
Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, United Kingdom.
出版信息
Front Neurosci. 2021 Jun 21;15:690896. doi: 10.3389/fnins.2021.690896. eCollection 2021.
INTRODUCTION
This study assessed the association of cerebral ischemia with neurodegeneration in mild cognitive impairment (MCI) and dementia.
METHODS
Subjects with MCI, dementia and controls underwent assessment of cognitive function, severity of brain ischemia, MRI brain volumetry and corneal confocal microscopy.
RESULTS
Of 63 subjects with MCI ( = 44) and dementia ( = 19), 11 had no ischemia, 32 had subcortical ischemia and 20 had both subcortical and cortical ischemia. Brain volume and corneal nerve measures were comparable between subjects with subcortical ischemia and no ischemia. However, subjects with subcortical and cortical ischemia had a lower hippocampal volume ( < 0.01), corneal nerve fiber length ( < 0.05) and larger ventricular volume ( < 0.05) compared to those with subcortical ischemia and lower corneal nerve fiber density ( < 0.05) compared to those without ischemia.
DISCUSSION
Cerebral ischemia was associated with cognitive impairment, brain atrophy and corneal nerve loss in MCI and dementia.
引言
本研究评估了轻度认知障碍（MCI）和痴呆症中脑缺血与神经退行性变之间的关联。
方法
对患有MCI、痴呆症的受试者以及对照组进行认知功能、脑缺血严重程度、脑部MRI容积测定和角膜共焦显微镜检查。
结果
在63名患有MCI（n = 44）和痴呆症（n = 19）的受试者中，11人无缺血，32人有皮质下缺血，20人既有皮质下缺血又有皮质缺血。皮质下缺血受试者与无缺血受试者之间的脑容量和角膜神经测量结果相当。然而，与皮质下缺血受试者相比，既有皮质下缺血又有皮质缺血的受试者海马体积较小（P < 0.01）、角膜神经纤维长度较短（P < 0.05）、脑室体积较大（P < 0.05）；与无缺血受试者相比，其角膜神经纤维密度较低（P < 0.05）。
讨论
脑缺血与MCI和痴呆症中的认知障碍、脑萎缩和角膜神经损伤有关。
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