Weill Cornell Medicine-Qatar Qatar Foundation Education City Doha Qatar.
Geriatric & Memory Clinic Rumailah Hospital Hamad Medical Corporation Doha Qatar.
Ann Clin Transl Neurol. 2019 Mar 2;6(4):689-697. doi: 10.1002/acn3.746. eCollection 2019 Apr.
Corneal confocal microscopy (CCM) is a noninvasive ophthalmic technique that identifies corneal nerve degeneration in a range of peripheral neuropathies and in patients with multiple sclerosis, Parkinson's disease, and amyotrophic lateral sclerosis. We sought to determine whether there is any association of corneal nerve fiber measures with cognitive function and functional independence in patients with MCI and dementia.
In this study, 76 nondiabetic participants with MCI ( = 30), dementia ( = 26), and healthy age-matched controls ( = 20) underwent assessment of cognitive and physical function and CCM.
There was a progressive reduction in corneal nerve fiber density (CNFD), branch density (CNBD), and fiber length (CNFL) ( < 0.0001) in patients with MCI and dementia compared to healthy controls. Adjusted for confounders, all three corneal nerve fiber measures were significantly associated with cognitive function ( < 0.05) and functional independence ( < 0.01) in MCI and dementia. The area under the ROC curve to distinguish MCI with CNFD, CNBD, and CNFL was 69.1%, 73.2%, and 73.0% and for dementia it was 84.8%, 84.2%, and 86.2%, respectively.
CCM demonstrates corneal nerve fiber loss, which is associated with a decline in cognitive function and functional independence in patients with MCI and dementia.
角膜共焦显微镜（CCM）是一种非侵入性眼科技术，可识别多种周围神经病变和多发性硬化症、帕金森病和肌萎缩侧索硬化症患者的角膜神经退行性变。我们试图确定角膜神经纤维测量值与 MCI 和痴呆患者的认知功能和功能独立性是否存在任何关联。
本研究纳入了 76 名非糖尿病性 MCI 患者（MCI 组=30 例）、痴呆患者（痴呆组=26 例）和年龄匹配的健康对照组（对照组=20 例），对他们进行认知和身体功能以及 CCM 评估。
与健康对照组相比，MCI 和痴呆患者的角膜神经纤维密度（CNFD）、分支密度（CNBD）和纤维长度（CNFL）均逐渐降低（<0.0001）。调整混杂因素后，所有三种角膜神经纤维测量值均与 MCI 和痴呆患者的认知功能（<0.05）和功能独立性（<0.01）显著相关。CNFD、CNBD 和 CNFL 区分 MCI 的 ROC 曲线下面积分别为 69.1%、73.2%和 73.0%，区分痴呆的 ROC 曲线下面积分别为 84.8%、84.2%和 86.2%。
CCM 显示角膜神经纤维丢失，与 MCI 和痴呆患者认知功能下降和功能独立性下降相关。
