Chen Dongshan, Li Dawei, Cui Zhanwu, Zhang Cong, Zhang Zhao, Yan Lei
Department of Urology, Qilu Hospital of Shandong University, Wenhuaxi Road 107#, Jinan, 250012, P.R. China.
Department of Urology, Second Traditional Chinese Medicine Hospital of Dezhou City, Zhongxing Road 245#, Dezhou , 253500, P.R. China.
J Cancer. 2021 Jun 16;12(16):5066-5075. doi: 10.7150/jca.45648. eCollection 2021.
To explore SA levels in the serum of urothelial tumor patients and their correlation with clinical pathological features and localization. Our research retrospectively collected data from 591 patients with urothelial tumors between July 2014 and April 2018. The SA levels in the serum of urothelial tumor patients and their correlation with clinical pathological features and localization were investigated. Univariate and multivariate logistic regression analyses were further performed to identify independent associations. The levels of SA were significantly associated with the malignant degree (tumor grade and infiltration) of bladder cancer and tumor localization (all < 0.05). The multivariate logistic regression model showed that SA levels were independently associated with the presence of high-grade urothelial carcinoma (BUC: HR = 1.941, UTUC: HR = 3.820, all <0.05) and upper urinary tract urothelial carcinoma (HR = 2.047, < 0.05). Finally, we validated the diagnosis and localization value of SA in an independent cohort from another institutions. Elevated serum SA levels are an independent predictor of high-grade urothelial carcinoma and upper urinary tract urothelial carcinoma, indicating that SA levels may be a potential biomarker for the diagnosis, prognosis and localization of urothelial tumors.
探讨尿路上皮肿瘤患者血清中唾液酸（SA）水平及其与临床病理特征和肿瘤部位的相关性。本研究回顾性收集了2014年7月至2018年4月期间591例尿路上皮肿瘤患者的数据。研究了尿路上皮肿瘤患者血清中的SA水平及其与临床病理特征和肿瘤部位的相关性。进一步进行单因素和多因素逻辑回归分析以确定独立关联。SA水平与膀胱癌的恶性程度（肿瘤分级和浸润）及肿瘤部位显著相关（均P<0.05）。多因素逻辑回归模型显示，SA水平与高级别尿路上皮癌的存在独立相关（膀胱尿路上皮癌：HR = 1.941，上尿路尿路上皮癌：HR = 3.820，均P<0.05）以及上尿路尿路上皮癌（HR = 2.047，P<0.05）。最后，我们在来自其他机构的独立队列中验证了SA的诊断和定位价值。血清SA水平升高是高级别尿路上皮癌和上尿路尿路上皮癌的独立预测指标，表明SA水平可能是尿路上皮肿瘤诊断、预后和定位的潜在生物标志物。
