变应性鼻炎与二胺氧化酶活性的关系：初步报告
Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report.
作者信息
Mayo-Yáñez Miguel, Díaz-Díaz Andrea, Vázquez-Barro Juan C, Herranz González-Botas Jesús, Figueroa Angélica, Martín-Martín Carlos S
机构信息
Otorhinolaryngology, Head and Neck Surgery Department, University Hospital Complex of A Coruña (CHUAC), A Coruña, Galicia.
Clinical Research in Medicine, International Center for Doctorate and Advanced Studies (CIEDUS), University of Santiago de Compostela (USC), Santiago de Compostela, Galicia.
出版信息
Allergol Select. 2021 Jun 18;5:187-194. doi: 10.5414/ALS400537. eCollection 2021.
AIM
To analyze the diamine oxidase (DAO), the main catabolic enzyme of histamine, degradation activity and its relation with symptoms of persistent allergic rhinitis.
METHODS
In this descriptive and analytical observational study, we collected DAO activity levels and the nasal peak inspiratory flow.
RESULTS
Enzymatic activity deficit in 108 patients was 46.3% (95% CI, 0.44 - 0.63), 33.33% in mild and 47.92% in moderate/severe rhinitis (p = 0.376). The nasal peak inspiratory flow in patients with a deficit in DAO activity was 76.30 ± 28.40 L/min compared to 93.62 ± 37.50 L/min in patients with normal enzymatic activity (p = 0.010).
CONCLUSIONS
It seems that the lower the catabolic activity of DAO, the lower the nasal peak inspiratory flow observed. Although DAO activity levels could be a severity biomarker in allergic rhinitis, a cause-effect association cannot be concluded. The enzyme could be another actor in the pathophysiology of allergic rhinitis.
目的
分析组胺的主要分解代谢酶二胺氧化酶（DAO）的降解活性及其与持续性变应性鼻炎症状的关系。
方法
在这项描述性和分析性观察研究中，我们收集了DAO活性水平和鼻吸气峰流量。
结果
108例患者的酶活性缺乏率为46.3%（95%CI，0.44 - 0.63），轻度鼻炎患者为33.33%，中度/重度鼻炎患者为47.92%（p = 0.376）。DAO活性缺乏患者的鼻吸气峰流量为76.30±28.40升/分钟，而酶活性正常患者为93.62±37.50升/分钟（p = 0.010）。
结论
似乎DAO的分解代谢活性越低，观察到的鼻吸气峰流量越低。尽管DAO活性水平可能是变应性鼻炎严重程度的生物标志物，但不能得出因果关联。该酶可能是变应性鼻炎病理生理学中的另一个因素。
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