John Curtin School of Medical Research (JCSMR), The Australian National University, ACT, Canberra, Australia.
Discipline of Optometry, Faculty of Health, University of Canberra, Bruce, ACT, 2617, Australia.
Graefes Arch Clin Exp Ophthalmol. 2021 Dec;259(12):3687-3696. doi: 10.1007/s00417-021-05296-9. Epub 2021 Jul 8.
To evaluate the association between ophthalmic structure/function measures and five standardized quality of life (QoL) instruments, in patients with advanced age-related macular degeneration (AMD).
We examined 20 AMD patients (ages 66-93 years) recruited from the Canberra Hospital Ophthalmology Department. Visual function measures included low and high contrast visual acuity (LCVA and HCVA) and measures from 10-2 Matrix visual fields (VF). Optical coherence tomography (OCT) quantified central retinal thickness (CRT), average macular thickness (AT), and retinal nerve fibre layer thickness (RNFL). The QoL instruments were the macular degeneration-related quality of life (MacDQoL), the National Eye Institute Visual Functioning Questionnaire (VFQ), its two face-recognition questions (A6 and 11), and the Geriatric Depression Scale (GDS). Pearson correlations, Canonical Correlation Analysis (CCA), and cross-validated stepwise-regression were used to examine the relationships between structure/function measures and the QoL instruments.
The selected models for the five instruments had R ranging from 0.65 ± 0.12 to 0.90 ± 0.05 (mean ± SD) and median F-statistics > 188. HCVA was strongly associated with all QoL except the GDS, for which CRT, AT and RNFL figured highly. RNFL was most important for MacDQoL, and 2 for VFQ question-A6. Centrally weighted VF measures were rarely selected but global VF measures were common, especially for the overall NEI-VFQ questionnaire. CCA revealed that the structure/function measures and QoL instruments contained 2 statistically independent mechanisms.
In patients with advanced AMD, CRT and HCVA were strong determinants of QoL instruments in AMD patients.
评估眼科结构/功能测量与五种标准化生活质量（QoL）工具在老年相关性黄斑变性（AMD）患者中的相关性。
我们检查了来自堪培拉医院眼科的 20 名 AMD 患者（年龄 66-93 岁）。视觉功能测量包括低对比度视力（LCVA）和高对比度视力（HCVA）以及 10-2 矩阵视野（VF）的测量值。光学相干断层扫描（OCT）定量了中心视网膜厚度（CRT）、平均黄斑厚度（AT）和视网膜神经纤维层厚度（RNFL）。QoL 工具包括与年龄相关性黄斑变性相关的生活质量（MacDQoL）、国家眼科研究所视觉功能问卷（VFQ）及其两个面部识别问题（A6 和 11）以及老年抑郁量表（GDS）。Pearson 相关、典型相关分析（CCA）和交叉验证逐步回归用于研究结构/功能测量与 QoL 工具之间的关系。
五个仪器的选定模型的 R 值范围为 0.65±0.12 至 0.90±0.05（平均值±标准差），中位数 F 统计量>188。HCVA 与所有 QoL 除 GDS 外均呈强相关，其中 CRT、AT 和 RNFL 高度相关。RNFL 对 MacDQoL 和 VFQ 问题 A6 最重要。中心加权 VF 测量很少被选择，但全局 VF 测量很常见，尤其是对于整个 NEI-VFQ 问卷。CCA 显示结构/功能测量和 QoL 工具包含两个统计学上独立的机制。
在晚期 AMD 患者中，CRT 和 HCVA 是 AMD 患者 QoL 工具的重要决定因素。
