Basaran Alim Emre, Vychopen Martin, Seidel Clemens, Barrantes-Freer Alonso, Arlt Felix, Güresir Erdem, Wach Johannes
Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany.
Comprehensive Cancer Center Central Germany, Partner Site Leipzig, 04103 Leipzig, Germany.
J Clin Med. 2024 Dec 25;14(1):40. doi: 10.3390/jcm14010040.
Sphenoid wing meningiomas (SWM) frequently compress structures of the optic pathway, resulting in significant visual dysfunction characterized by vision loss and visual field deficits, which profoundly impact patients' quality of life (QoL), daily activities, and independence. The objective of this study was to assess the impact of SWM surgery on patient-reported outcome measures (PROMs) regarding postoperative visual function. The Visual Function Score Questionnaire (VFQ-25) is a validated tool designed to assess the impact of visual impairment on quality of life. The questionnaire was distributed to a previously published study population in which shape radiomics were correlated with new cranial nerve deficits after SWM surgery. A total of 42 patients (42/74; 56.8%) responded to the questionnaire. Of the 42 patients, 30 were female (71%) and 12 were male (29%). The multivariable analysis demonstrated that lower sphericity reflecting irregular SWM shape was associated with poorer VFQ-25 (OR: 6.8, 95% CI: 1.141.8, = 0.039), while age was associated with lower VFQ-25 (OR: 27, 95% CI: 2.7-272.93, = 0.005), too. Analysis of the subcategories of the VFQ-25 revealed significantly reduced general vision ( = 0.045), social functioning ( = 0.045), and peripheral vision ( = 0.017) in those with SWM with low sphericity. The study highlights that SWM surgery impacts postoperative visual function, with age and irregular SWM shape being associated with poorer postoperative VFQ-25 scores. VFQ-25 is a feasible tool to assess vision outcome in SWM surgery and has clinical potential for longitudinal follow-up evaluations. Irregular SWM shape should be considered during preoperative treatment planning and patient consultation regarding functional outcome.
蝶骨嵴脑膜瘤（SWM）常压迫视路结构，导致以视力丧失和视野缺损为特征的严重视觉功能障碍，这对患者的生活质量（QoL）、日常活动和独立性产生深远影响。本研究的目的是评估SWM手术对患者报告的术后视觉功能结局指标（PROMs）的影响。视觉功能评分问卷（VFQ-25）是一种经过验证的工具，旨在评估视力损害对生活质量的影响。该问卷被分发给先前发表的一项研究中的人群，该研究中形状放射组学与SWM手术后新出现的颅神经缺损相关。共有42名患者（42/74；56.8%）回复了问卷。在这42名患者中，30名女性（71%），12名男性（29%）。多变量分析表明，反映SWM形状不规则的较低球度与较差的VFQ-25相关（OR：6.8，95%CI：1.14-1.8，P = 0.039），而年龄也与较低的VFQ-25相关（OR：27，95%CI：2.7-272.93，P = 0.005）。对VFQ-25子类别的分析显示，球度低的SWM患者的总体视力（P = 0.045）、社会功能（P = 0.045）和周边视力（P = 0.017）显著降低。该研究强调，SWM手术会影响术后视觉功能，年龄和SWM形状不规则与术后较差的VFQ-25评分相关。VFQ-25是评估SWM手术视力结局的可行工具，在纵向随访评估中具有临床潜力。在术前治疗规划和关于功能结局的患者咨询中应考虑SWM形状不规则的情况。
