Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
Adv Drug Deliv Rev. 2021 Sep;176:113856. doi: 10.1016/j.addr.2021.113856. Epub 2021 Jul 5.
The symbiotic microbiota is nowadays regarded as a human "invisible organ", its imbalance has been shown to be associated with many diseases. Besides, the progress of diseases can in turn change the internal structure of microbiota. Some diseases have shown their unique microbiota markers that may be potential therapeutic targets. Therefore, modulating microbiota may be a powerful strategy for diseases treatment. However, conventional microbiota modulation strategies lack selectivity and are suffer from side effects. In recent years, with the increasing challenge of antibiotic resistance, bacteriophage (phage) therapy has gradually presented its potential to treat drug-resistant infections. Phages are viruses that infect bacteria, with high selectivity for specific bacteria and almost no tropism for mammalian cells. Studies showed that phage-mediated precise modulation of microbiota has achieved great success in diseases treatment. Here, we briefly summarized the treatment strategies of phage-mediated modulation of microbiota, and discussed prospect of possible development in this field.
目前，共生微生物群被视为人体的“隐形器官”，其失衡与许多疾病有关。此外，疾病的进展反过来也会改变微生物群的内部结构。一些疾病已经表现出其独特的微生物群标志物，这些标志物可能是潜在的治疗靶点。因此，调节微生物群可能是一种治疗疾病的有效策略。然而，传统的微生物群调节策略缺乏选择性，并存在副作用。近年来，随着抗生素耐药性的日益增加，噬菌体（phage）治疗逐渐显示出治疗耐药性感染的潜力。噬菌体是感染细菌的病毒，对特定细菌具有高度选择性，几乎对哺乳动物细胞没有趋向性。研究表明，噬菌体介导的精确调节微生物群在疾病治疗中取得了巨大成功。在这里，我们简要总结了噬菌体介导的微生物群调节的治疗策略，并讨论了该领域可能的发展前景。
