Warwick Medical School, University of Warwick, Coventry, UK.
University of Birmingham, Birmingham, UK.
J Med Microbiol. 2024 Sep;73(9). doi: 10.1099/jmm.0.001895.
Recently, bacteriophages have been considered alternatives to antibacterial treatments. Infectious diseases continue to plague the world because bacteria can adapt and develop defence mechanisms against antibiotics. The growing incidence of antibiotic-resistant bacterial infections necessitated the development of new techniques for treating bacterial infections worldwide. Clinical trials have shown efficiency against antibiotic-resistant bacteria. However, scientists in future clinical trials should scrutinize phage resistance implications, assess combination strategies with antimicrobial agents and address challenges in phage therapy delivery for effective implementation.
最近,噬菌体被认为是替代抗菌治疗的方法。传染病继续困扰着世界,因为细菌可以对抗生素产生适应性并发展防御机制。抗生素耐药性细菌感染的发病率不断上升,这使得全世界都需要开发新的技术来治疗细菌感染。临床试验已显示出对耐药菌的有效性。然而,未来的临床试验中的科学家应该仔细研究噬菌体耐药性的影响,评估与抗菌药物联合使用的策略,并解决噬菌体治疗传递中的挑战,以实现有效的实施。