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噬菌体治疗的临床试验现状。

Current status of clinical trials for phage therapy.

机构信息

Warwick Medical School, University of Warwick, Coventry, UK.

University of Birmingham, Birmingham, UK.

出版信息

J Med Microbiol. 2024 Sep;73(9). doi: 10.1099/jmm.0.001895.

Abstract

Recently, bacteriophages have been considered alternatives to antibacterial treatments. Infectious diseases continue to plague the world because bacteria can adapt and develop defence mechanisms against antibiotics. The growing incidence of antibiotic-resistant bacterial infections necessitated the development of new techniques for treating bacterial infections worldwide. Clinical trials have shown efficiency against antibiotic-resistant bacteria. However, scientists in future clinical trials should scrutinize phage resistance implications, assess combination strategies with antimicrobial agents and address challenges in phage therapy delivery for effective implementation.

摘要

最近,噬菌体被认为是替代抗菌治疗的方法。传染病继续困扰着世界,因为细菌可以对抗生素产生适应性并发展防御机制。抗生素耐药性细菌感染的发病率不断上升,这使得全世界都需要开发新的技术来治疗细菌感染。临床试验已显示出对耐药菌的有效性。然而,未来的临床试验中的科学家应该仔细研究噬菌体耐药性的影响,评估与抗菌药物联合使用的策略,并解决噬菌体治疗传递中的挑战,以实现有效的实施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1a3/11423923/17e75b6f19cb/jmm-73-01895-g001.jpg

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