Department of Respirology & Allergy. Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, Guangdong Province, PR China; School of Public Health, Health Science Center, Shenzhen University, Shenzhen 518060, Guangdong Province, PR China.
College of Life Science, Shenzhen University, Shenzhen 518060, Guangdong Province, PR China.
Food Chem. 2021 Nov 15;362:130231. doi: 10.1016/j.foodchem.2021.130231. Epub 2021 May 28.
The silkworm (Bombyx mori) is an important economic insect that can be used as food in many countries in Asia. However, silkworms and their metabolites are an important source of allergens, which can induce severe allergic reactions. So far, there are no systematic studies on the potential allergens in silkworm and its metabolites. These studies have important guiding significance for the prevention, diagnosis, and treatment of silkworm allergy. The aim of this study was to identify the potential allergens from larva, pupa, moth, silk, slough and feces of silkworm and analyze the sequence homology of silkworm allergens with other allergens identified in the Allergenonline database. We have found 45 potential allergens in silkworm. The results of the homology comparison suggested that silkworm allergens likely cross-react with those of Dermatophagoides farinae, Aedes aegypti, Tyrophagus putrescentiae, Triticum aestivum and Malassezia furfur.
家蚕（Bombyx mori）是一种重要的经济昆虫，在亚洲的许多国家都被用作食物。然而，家蚕及其代谢物是过敏原的重要来源，可能会引起严重的过敏反应。目前，还没有系统研究家蚕及其代谢物中的潜在过敏原。这些研究对家蚕过敏的预防、诊断和治疗具有重要的指导意义。本研究旨在从家蚕幼虫、蛹、蛾、丝、蜕皮和粪便中鉴定潜在的过敏原，并分析家蚕过敏原与 Allergenonline 数据库中鉴定的其他过敏原的序列同源性。我们在家蚕中发现了 45 种潜在的过敏原。同源性比较的结果表明，家蚕过敏原可能与粉尘螨、埃及伊蚊、腐食酪螨、普通小麦和糠秕马拉色菌发生交叉反应。
