Hirschberg M, Korves M, Koc I, Hofferberth B, Wiesmann W
Klinik für Neurologie und Radiologie, Universität Münster.
Schweiz Med Wochenschr. 1987 Nov 14;117(46):1811-3.
The majority of ischemic cerebral insults are caused by thromboembolism. In animal experiments we have investigated the possibility of reperfusing ischemically damaged brain tissue by thrombolysis of cerebral emboli. 1, 3 and 5 hours after cerebral infarction due to thromboembolism, thrombolytic treatment with urokinase (1000 IU/kg/min) was started. Thrombolysis, monitored by angiography, was successful in all cases (n = 15). In all cases the fall in fibrinogen, alpha 2-antiplasmin and plasminogen reflected systemic fibrinolytic effects. Anatomo-pathologic investigation of the brains revealed no intracerebral bleeding complications. The results of the study suggest a favourable effect of urokinase on acute ischemic cerebral infarction.
大多数缺血性脑损伤是由血栓栓塞引起的。在动物实验中，我们研究了通过溶解脑栓塞对缺血性损伤的脑组织进行再灌注的可能性。在血栓栓塞导致脑梗死1、3和5小时后，开始用尿激酶（1000 IU/kg/分钟）进行溶栓治疗。通过血管造影监测，溶栓在所有病例（n = 15）中均成功。在所有病例中，纤维蛋白原、α2-抗纤溶酶和纤溶酶原的下降反映了全身纤溶作用。对大脑的解剖病理学研究未发现脑内出血并发症。该研究结果表明尿激酶对急性缺血性脑梗死有良好作用。
