Neftel K, Fontana A, Guggenheim M, Schenker T, Gmür J, von Felten A, Marti C, Frick P G
Medizinische Klinik, Universitätsspital, Zürich.
Schweiz Med Wochenschr. 1987 Nov 14;117(46):1824-7.
Clinical and serological data in 5 cases of autoimmune hemolysis following therapy with Catergen are reported and compared to the data in similar literature reports. The main argument in favour of Catergen as causative agent in our 5 cases was rapid remission of hemolysis within 2 1/2 to 10 weeks of withdrawing Catergen treatment. Besides causing hemolysis mediated by drug dependent antibodies, long term treatment with Catergen may induce formation of IgG autoantibodies against red blood cells with or without overt hemolysis.
报告了5例服用卡特金后发生自身免疫性溶血的临床和血清学数据，并与类似文献报告中的数据进行了比较。支持卡特金是我们这5例病例病因的主要依据是，在停用卡特金治疗后的2.5至10周内溶血迅速缓解。除了引起药物依赖性抗体介导的溶血外，长期使用卡特金治疗可能会诱导针对红细胞的IgG自身抗体形成，无论是否有明显溶血。
