Division of Hematology, Department of Internal Medicine, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Division of Hematology, Department of Pedriatrics, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Hematology. 2021 Dec;26(1):473-477. doi: 10.1080/16078454.2021.1943829.
Liver iron overload is common in patients with thalassemia. In patients with beta-thalassemia, the correlation between serum ferritin and liver iron concentration is well established. The correlation between serum ferritin levels and liver iron concentrations in patients with alpha-thalassemia remains limited.
This is a cross-sectional study in patients with alpha-thalassemia aged ≥ 18 years old at Srinagarind Hospital, Khon Kaen University, Thailand. Liver iron concentration (LIC) was evaluated by the MRI-T2* technique. Linear logistic regression analysis was used to determine the correlation between serum ferritin levels and liver iron concentrations.
One hundred and thirty-one of the MRI-T2* measurements from 65 patients with alpha-thalassemia were evaluated. Patients with non-deletional alpha-thalassemia had higher LIC compared to patients with deletional alpha-thalassemia. The serum ferritin levels were relatively low at the same levels of LIC in patients with non-deletional alpha-thalassemia compared to deletional alpha-thalassemia
The correlation of serum ferritin levels and LIC was modest and different among alpha-thalassemia genotypes. A different serum ferritin threshold is needed to guide iron chelation therapy in patients with alpha-thalassemia. Evaluation of liver iron concentration is necessary for patients with alpha-thalassemia, especially in patients with non-deletional alpha-thalassemia.
铁过载在β地中海贫血患者中很常见。在β地中海贫血患者中，血清铁蛋白与肝铁浓度之间的相关性已得到充分证实。α地中海贫血患者的血清铁蛋白水平与肝铁浓度之间的相关性仍然有限。
这是一项在泰国孔敬大学诗琳通医院年龄≥18 岁的α地中海贫血患者中进行的横断面研究。通过 MRI-T2*技术评估肝铁浓度（LIC）。线性逻辑回归分析用于确定血清铁蛋白水平与肝铁浓度之间的相关性。
对 65 例α地中海贫血患者的 131 次 MRI-T2*测量进行了评估。非缺失型α地中海贫血患者的 LIC 高于缺失型α地中海贫血患者。与缺失型α地中海贫血患者相比，非缺失型α地中海贫血患者在相同的 LIC 水平下血清铁蛋白水平相对较低。
血清铁蛋白水平与 LIC 的相关性在不同的α地中海贫血基因型之间存在差异且适度。α地中海贫血患者需要不同的血清铁蛋白阈值来指导铁螯合治疗。对于α地中海贫血患者，特别是对于非缺失型α地中海贫血患者，需要评估肝铁浓度。
