新西兰新冠封锁期间帕金森病患者感知压力增大且运动症状恶化。
Higher perceived stress and exacerbated motor symptoms in Parkinson's disease during the COVID-19 lockdown in New Zealand.
机构信息
PhD; New Zealand Brain Research Institute, Christchurch, New Zealand; School of Physical Education, Sport and Exercise Sciences, University of Otago, Dunedin, New Zealand; Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
BSc; New Zealand Brain Research Institute, Christchurch, New Zealand.
出版信息
N Z Med J. 2021 Jul 9;134(1538):44-51.
AIMS
Stress plays a key role in Parkinson's disease (PD) by acting on the dopaminergic system and worsening patients' motor function. The impact of New Zealand's strict lockdown measures to contain COVID-19 on perceived stress and PD motor symptoms remains unknown. Here we examined the relationship between perceived levels of stress, changes in physical activity levels and PD motor symptoms during lockdown.
METHODS
During lockdown, 134 participants with PD and 49 controls completed a survey assessing perceived stress, self-reported changes in PD motor symptoms and physical activity duration and intensity prior to and during lockdown.
RESULTS
Perceived stress was higher in PD than controls, and in those reporting a worsening of tremor, balance/gait, dyskinesia and bradykinesia compared to those indicating no change during the COVID-19 lockdown. These effects were not modulated by physical activity.
CONCLUSIONS
Reducing stressors may be an important adjunct treatment strategy to improve motor function in PD.
目的
压力通过作用于多巴胺能系统对帕金森病（PD）起着关键作用，并使患者的运动功能恶化。新西兰为控制 COVID-19 而实施的严格封锁措施对感知压力和 PD 运动症状的影响尚不清楚。在这里，我们研究了封锁期间感知压力水平、体力活动水平变化与 PD 运动症状之间的关系。
方法
在封锁期间，134 名 PD 患者和 49 名对照者完成了一项调查，评估了感知压力、自我报告的 PD 运动症状变化以及封锁前和封锁期间的体力活动持续时间和强度。
结果
与报告震颤、平衡/步态、运动障碍和运动迟缓无变化的患者相比，PD 患者的感知压力更高，与 COVID-19 封锁期间报告震颤、平衡/步态、运动障碍和运动迟缓恶化的患者相比，PD 患者的感知压力更高。这些影响不受体力活动的调节。
结论
减少压力源可能是改善 PD 运动功能的重要辅助治疗策略。
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