Movement Disorders Center, Neurological Institute, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.
Int J Mol Sci. 2024 Nov 19;25(22):12409. doi: 10.3390/ijms252212409.
Parkinson's disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted the need for a multi-target DMT approach in PD that recognizes the various risk factors and their intricate interplay in contributing to PD-related neurodegeneration. Widespread risk factors, such as emotional stress and metabolic factors, have increasingly become focal points of exploration. Our review aims to summarize interactions between emotional stress and selected key players in metabolism, such as insulin, as potential mechanisms underlying neurodegeneration in PD.
帕金森病（PD）是一种常见的神经退行性疾病，目前只有对症治疗方法，而没有疾病修正疗法（DMT）。多年来的广泛研究强调了 PD 需要一种多靶点 DMT 方法，该方法认识到各种风险因素及其在导致 PD 相关神经退行性变中的复杂相互作用。广泛的风险因素，如情绪压力和代谢因素，已越来越成为探索的焦点。我们的综述旨在总结情绪压力与代谢中的某些关键因素（如胰岛素）之间的相互作用，作为 PD 中神经退行性变的潜在机制。
