长链非编码RNA GAU1诱导GALNT8过表达并促进结直肠癌进展。
lncRNA GAU1 Induces GALNT8 Overexpression and Potentiates Colorectal Cancer Progression.
作者信息
Tang Xuemei, Ruan Haoyu, Dong Liu, Li Sihan, Wu Zhiyuan, Guan Ming
机构信息
Department of Laboratory Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China.
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, PA 15261, USA.
出版信息
Gastroenterol Res Pract. 2021 Jun 17;2021:5960821. doi: 10.1155/2021/5960821. eCollection 2021.
lncRNA is a key epigenetic regulator in biological processes. In the human cancer transcriptome library MiTranscriptome, we identified as the top upregulated lncRNA in colorectal cancer (CRC) by sample set enrichment analysis (overexpression ranking percentile = 99.75%, < 10), which is coexpressed with the potential oncogene (Spearman rho = 0.67, = 2.44 × 10, TCGA dataset = 184). Experimental data revealed that regulates the expression of . The overexpression of either or significantly promotes the cell cycle and proliferation of CRC cell lines and correlates with poor prognosis in patients with CRC ( = 3.04 × 10), while silencing of or suppressed the cancer cell proliferation and induced the CRC cell line resistance to oxaliplatin treatment. Our results suggested that the previously less studied and may play as CRC prognosis markers and potential targets for chemotherapy treatment.
长链非编码RNA（lncRNA）是生物过程中的关键表观遗传调节因子。在人类癌症转录组文库MiTranscriptome中，通过样本集富集分析，我们确定其为结直肠癌（CRC）中上调最明显的lncRNA（过表达排名百分位数=99.75%，<10），它与潜在癌基因共表达（斯皮尔曼相关系数=0.67，=2.44×10，TCGA数据集=184）。实验数据表明，调节的表达。或的过表达均显著促进CRC细胞系的细胞周期和增殖，并与CRC患者的不良预后相关（=3.04×10），而或的沉默则抑制癌细胞增殖并诱导CRC细胞系对奥沙利铂治疗产生抗性。我们的结果表明，此前研究较少的和可能作为CRC预后标志物及化疗治疗的潜在靶点。
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