马蔺酰胺 F 具有抗炎和抗伤害感受活性，可在炎症大鼠模型中发挥作用。
Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation.
机构信息
Department of Anesthesiology, Heilongjiang Provincial Hospital, No. 82 Zhongshan Road, Xiangfang District, Harbin City, Heilongjiang Province 150036, China.
Department of Anesthesiology, Harbin Chest Hospital, No. 417 Xianfeng Road, Daowai District, Harbin City, Heilongjiang Province 150026, China.
出版信息
Pain Res Manag. 2021 Jun 18;2021:4919391. doi: 10.1155/2021/4919391. eCollection 2021.
OBJECTIVE
Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F.
METHODS
The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-, PGE-2, and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA).
RESULTS
Maltoamide F was safe at oral doses of 1-10 mg/kg for rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) notably reduced carrageenan-induced edema percentage of paws in rats and decreased levels of PGE-2, IL-6, and TNF- in homogenates of foot tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF- in foot tissues of formalin-induced rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) repressed AA-induced increase of ear thickness in rats and reduced levels of PGE-2, IL-6, and TNF- in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced xylene-induced weight of ear edema in rats and reduced levels of PGE-2, IL-6, and TNF- in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF- in homogenates of cotton ball granuloma of cotton-pellet-induced rats.
CONCLUSIONS
Maltoamide F possessed anti-inflammatory and analgesic activity in inflammatory models of rats.
目的
炎症和疼痛与各种临床病症的病理生理学有关。本研究旨在探究麦芽酰胺 F 的镇痛和抗炎活性。
方法
通过急性毒性试验评估麦芽酰胺 F 的可能毒性。为了评估麦芽酰胺 F 对大鼠的抗炎和镇痛作用，建立了角叉菜胶诱导的足肿胀、二甲苯诱导的耳肿胀、花生四烯酸诱导的耳肿胀、甲醛诱导的足底肿胀和棉球肉芽肿模型。通过酶联免疫吸附试验（ELISA）检测 TNF-、PGE-2 和 IL-6 的水平。
结果
麦芽酰胺 F 在 1-10mg/kg 口服剂量下对大鼠是安全的。麦芽酰胺 F（1mg/kg、5mg/kg 和 10mg/kg）显著降低了角叉菜胶诱导的大鼠足肿胀百分比，并降低了足部组织匀浆中 PGE-2、IL-6 和 TNF-的水平。麦芽酰胺 F（1mg/kg、5mg/kg 和 10mg/kg）降低了甲醛诱导的大鼠足部组织中 PGE-2、IL-6 和 TNF-的水平。麦芽酰胺 F（1mg/kg、5mg/kg 和 10mg/kg）抑制了 AA 诱导的大鼠耳厚度增加，并降低了耳部组织匀浆中 PGE-2、IL-6 和 TNF-的水平。麦芽酰胺 F（1mg/kg、5mg/kg 和 10mg/kg）降低了二甲苯诱导的大鼠耳肿胀重量，并降低了耳部组织匀浆中 PGE-2、IL-6 和 TNF-的水平。麦芽酰胺 F（1mg/kg、5mg/kg 和 10mg/kg）降低了棉球肉芽肿诱导的大鼠棉球肉芽肿组织匀浆中 PGE-2、IL-6 和 TNF-的水平。
结论
麦芽酰胺 F 在大鼠炎症模型中具有抗炎和镇痛活性。
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