Zou Linjun, Hou Yong, Zhang Jiawen, Chen Meiying, Wu Peiying, Feng Changcun, Li Qinglong, Xu Xudong, Sun Zhaocui, Ma Guoxu
Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education; Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100193, China.
School of Pharmacy; Guangxi Medical University, Nanning, 530021, China.
Mater Today Bio. 2023 Aug 3;22:100755. doi: 10.1016/j.mtbio.2023.100755. eCollection 2023 Oct.
Postoperative peritoneal adhesion (PPA) is frequent and extremely dangerous complication after surgery. Different tactics have been developed to reduce it. However, creating a postoperative adhesion method that is multifunctional, biodegradable, biocompatible, low-toxic but highly effective, and therapeutically applicable is still a challenge. Herein, we have prepared a degradable spray glycyrrhetinic acid hydrogel (GAG) based on natural glycyrrhetinic acid (GA) by straightforward heating and cooling without the use of any additional chemical cross-linking agents to prevent postoperative adhesion. The resultant hydrogel was demonstrated to possess various superior anti-inflammatory activity, and multiple functions, such as excellent degradability and biocompatibility. Specifically, spraying characteristic and excellent antibacterial activities essentially eliminated secondary infections during the administration of drugs in surgical wounds. In the rat models, the carrier-free spray GAG could not only slow-release GA to inhibit inflammatory response, but also serve as physical anti-adhesion barrier to reduce collagen deposition and fibrosis. The sprayed GAG would shed a new light on the prevention of postoperative adhesion and broaden the application of the hydrogels based on natural products in biomedical fields.
术后腹膜粘连（PPA）是手术后常见且极其危险的并发症。人们已经开发出不同的策略来减少这种情况。然而，创建一种多功能、可生物降解、生物相容、低毒但高效且具有治疗适用性的术后粘连防治方法仍然是一项挑战。在此，我们通过简单的加热和冷却，在不使用任何额外化学交联剂的情况下，基于天然甘草次酸（GA）制备了一种可降解的喷雾型甘草次酸水凝胶（GAG），以预防术后粘连。结果表明，所得水凝胶具有多种优异的抗炎活性以及多种功能，如出色的可降解性和生物相容性。具体而言，喷雾特性和出色的抗菌活性基本上消除了手术伤口给药过程中的继发感染。在大鼠模型中，无载体喷雾型GAG不仅能缓释GA以抑制炎症反应，还能作为物理抗粘连屏障减少胶原蛋白沉积和纤维化。所喷洒的GAG将为预防术后粘连带来新的思路，并拓宽基于天然产物的水凝胶在生物医学领域的应用。
