Vijayasekharan Kalasekhar, Gupta Nitin, Reddisetti Suhas, Saravu Kavitha, Godkhindi Vishwapriya M
Paediatric Haematology and Oncology, Manipal Comprehensive Cancer Care Centre, Manipal Academy of Higher Education, Manipal, IND.
Infectious Diseases, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, IND.
Cureus. 2021 May 31;13(5):e15362. doi: 10.7759/cureus.15362. eCollection 2021 May.
Disseminated cryptococcosis in children is a classic affliction associated with human immunodeficiency virus (HIV) infection or primary inherited immunodeficiency disorders (PID) with central nervous system being the most common site of dissemination. We report a rare case of disseminated cryptococcosis in an 11-year-old girl who presented with pulmonary involvement, hepatosplenomegaly, and generalized lymphadenopathy. No known inherited or acquired immune deficiencies were identified after a comprehensive laboratory work-up including genetic sequencing. She responded well to anti-fungal therapy (flucytosine and amphotericin followed by fluconazole) and is on regular follow-up.
儿童播散性隐球菌病是一种与人类免疫缺陷病毒（HIV）感染或原发性遗传性免疫缺陷疾病（PID）相关的典型病症，中枢神经系统是最常见的播散部位。我们报告了一例罕见的11岁女孩播散性隐球菌病病例，该女孩表现为肺部受累、肝脾肿大和全身淋巴结肿大。经过包括基因测序在内的全面实验室检查，未发现已知的遗传性或获得性免疫缺陷。她对抗真菌治疗（氟胞嘧啶和两性霉素，随后是氟康唑）反应良好，目前正在定期随访中。
