异种抗淋巴细胞血清对初次免疫反应的抑制作用。
Suppression of primary immune response by heterologous anti-lymphocyte sera.
作者信息
Reuben C, Sundaram K, Phondke G P
出版信息
Immunology. 1978 Feb;34(2):223-30.
The effect of anti-lymphocyte serum (ALS) on the primary immune response to sheep erythrocytes (SRBC) in rats was studied by the Jerne Plaque technique. ALS against normal rat lymph node cells, ALS(N) suppressed the immune response to SRBC when administered before the antigen and had no effect on the immune response when administered either with or after the antigen. ALS(I), which was produced against lymph node cells from SRBC immunized rats, produced significant immunosuppression when administered either before or after the antigen.
采用耶尔恩斑技术研究了抗淋巴细胞血清（ALS）对大鼠针对绵羊红细胞（SRBC）的初次免疫反应的影响。针对正常大鼠淋巴结细胞的抗淋巴细胞血清ALS（N），在抗原注射前给药时可抑制对SRBC的免疫反应，而在与抗原同时给药或在抗原注射后给药时对免疫反应无影响。针对经SRBC免疫的大鼠淋巴结细胞产生的抗淋巴细胞血清ALS（I），在抗原注射前或注射后给药时均产生显著的免疫抑制作用。
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