Johnson J A, Lau B H, Nutter R L, Slater J M, Winter C E
Infect Immun. 1978 Jan;19(1):146-51. doi: 10.1128/iai.19.1.146-151.1978.
This study was carried out to determine whether animals bearing L1210 leukemia were more susceptible to candida infection in the absence of immunosuppression and to determine also if the L1210 cells suppressed the inflammatory response of the animal host. Systemic infection was studied by intravenous injection of Candida albicans and checking for the number of candida organisms cultured from the blood and the kidneys. Localized infection was studied by intramuscular injection of C. albicans into the thighs and measuring the changes in the thigh size. Compared with tumor-free controls, the intravenous injection resulted in higher counts of C. albicans from the blood and the kidneys of tumor-bearing animals. No significant difference in the localized swelling was noted between tumor- and nontumor-bearing mice with respect to intramuscular injection of C. albicans. The results thus indicate that L1210 leukemia increases susceptibility of tumor-bearing animals to systemic candida infection. L1210 cells were shown to reduce the accumulation of neutrophils and to suppress the inflammatory reaction elicited by C. albicans.
本研究旨在确定携带L1210白血病的动物在无免疫抑制情况下是否更易感染念珠菌，同时也确定L1210细胞是否会抑制动物宿主的炎症反应。通过静脉注射白色念珠菌并检查从血液和肾脏培养出的念珠菌数量来研究全身感染。通过将白色念珠菌肌肉注射到大腿并测量大腿大小的变化来研究局部感染。与无肿瘤对照组相比，静脉注射导致携带肿瘤动物的血液和肾脏中白色念珠菌的计数更高。在肌肉注射白色念珠菌方面，携带肿瘤和未携带肿瘤的小鼠在局部肿胀方面没有显著差异。因此，结果表明L1210白血病会增加携带肿瘤动物对全身性念珠菌感染的易感性。研究表明，L1210细胞会减少中性粒细胞的积累，并抑制白色念珠菌引发的炎症反应。
