Fielden E M, Sapora O, Loverock P S
Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Jan;33(1):41-5. doi: 10.1080/09553007714551471.
Concentration versus radiosensitizing effect curves have been determined for four E. coli strains with two nitroaromatic sensitizers. The data are consistent with a simple competition kinetic model of sensitization, and K values for Ro 07-0582 are reported. An empirical relationship, DMF=alpha o.e.r., relating the dose-modifying factor produced by a given concentration of sensitizer to the oxygen-enhancement ratio of a bacterium was found to hold for all the mutants tested for values of alpha greater than 1/o.e.r. The limiting value of alpha at high concentrations of sensitizer was 0.75. Some implications of this relationship and the limiting value of alpha are discussed.
已经用两种硝基芳香族敏化剂测定了四种大肠杆菌菌株的浓度与放射增敏效应曲线。数据与敏化的简单竞争动力学模型一致，并报告了Ro 07 - 0582的K值。对于所有测试的突变体，当α值大于1 /氧增强比（o.e.r.）时，发现一种经验关系DMF =α×o.e.r.成立，该关系将给定浓度敏化剂产生的剂量修正因子与细菌的氧增强比联系起来。在高浓度敏化剂下α的极限值为0.75。讨论了这种关系和α极限值的一些含义。
